The Double Face of Mucin-Type O-Glycans in Lectin-Mediated Infection and Immunity.
The Double Face of Mucin-Type O-Glycans in Lectin-Mediated Infection and Immunity.
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DOI：
10.3390/molecules23051151
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发表时间：
2018-05-11
期刊：
影响因子：
--
通讯作者：
Hanisch FG
中科院分区：
文献类型：
--
作者：
Morozov V;Borkowski J;Hanisch FG
O-聚糖上的上皮人类血型抗原（HBGAs）在病原体结合和感染起始中发挥作用，而分泌粘蛋白上的类似结构发挥保护功能。本文以细菌和病毒病原体为例，综述了O-聚糖在感染和先天免疫中的双重作用。幽门螺杆菌是人类胃中的一类致癌物质。通过表达分别与Lewis-b和LacdiNAc结合的血型抗原结合粘附素（BabA）和LabA粘附素，H.幽门螺杆菌与胃表面上皮中的粘蛋白MUC 5AC共定位，但不与MUC 6共定位，MUC 6由胃深腺与三叶因子家族2（TFF 2）共分泌。腺分泌体的两种组分在感染后一致上调。而MUC 6表达GlcNAc-封端的聚糖作为H. pylori生长控制，TFF 2可以作为益生菌凝集素发挥作用。在病毒感染中，GII基因组的人诺如病毒通过其主要衣壳蛋白VP 1与HBGA相互作用。母乳低聚糖（HMO）上的HBGA可能通过与衣壳上的P2结构域口袋结合而发挥保护功能。我们讨论了与血型H/Lewis-b HMO和岩藻聚糖衍生的低聚岩藻糖相互作用的P2碳水化合物结合口袋的结构细节，作为最流行的诺如病毒株GII.4和GII.17的有效相互作用物。
Epithelial human blood group antigens (HBGAs) on O-glycans play roles in pathogen binding and the initiation of infection, while similar structures on secretory mucins exert protective functions. These double-faced features of O-glycans in infection and innate immunity are reviewed based on two instructive examples of bacterial and viral pathogens. Helicobacter pylori represents a class 1 carcinogen in the human stomach. By expressing blood group antigen-binding adhesin (BabA) and LabA adhesins that bind to Lewis-b and LacdiNAc, respectively, H. pylori colocalizes with the mucin MUC5AC in gastric surface epithelia, but not with MUC6, which is cosecreted with trefoil factor family 2 (TFF2) by deep gastric glands. Both components of the glandular secretome are concertedly up-regulated upon infection. While MUC6 expresses GlcNAc-capped glycans as natural antibiotics for H. pylori growth control, TFF2 may function as a probiotic lectin. In viral infection human noroviruses of the GII genogroup interact with HBGAs via their major capsid protein, VP1. HBGAs on human milk oligosaccharides (HMOs) may exert protective functions by binding to the P2 domain pocket on the capsid. We discuss structural details of the P2 carbohydrate-binding pocket in interaction with blood group H/Lewis-b HMOs and fucoidan-derived oligofucoses as effective interactors for the most prevalent norovirus strains, GII.4 and GII.17.
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影响因子：
3
作者：
Fiege, Brigitte;Leuthold, Mila;Peters, Thomas
通讯作者：
Peters, Thomas
影响因子：
19
作者：
Fu, J.;Ai, J.;Zhu, Y.
通讯作者：
Zhu, Y.
幽门螺杆菌胃上皮细胞粘附和 CagA 注射的分子机制。
DOI：
10.1186/1478-811x-9-28
发表时间：
2011-11-01
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
Backert S;Clyne M;Tegtmeyer N
通讯作者：
Tegtmeyer N
影响因子：
3.7
作者：
Eden, John-Sebastian;Hewitt, Joanne;Lim, Kun Lee;Boni, Maciej F.;Merif, Juan;Greening, Gail;Ratcliff, Rodney M.;Holmes, Edward C.;Tanaka, Mark M.;Rawlinson, William D.;White, Peter A.
通讯作者：
White, Peter A.
影响因子：
5.4
作者：
de Rougemont, A.;Ruvoen-Clouet, N.;Belliot, G.
通讯作者：
Belliot, G.