Association between the lipoprotein-associated phospholipase A2 activity and the progression of subclinical atherosclerosis.
Association between the lipoprotein-associated phospholipase A2 activity and the progression of subclinical atherosclerosis.
复制标题
脂蛋白相关磷脂酶 A2 活性与亚临床动脉粥样硬化进展之间的关联。
DOI：
10.5551/jat.20941
复制
发表时间：
2014-06
影响因子：
4.4
通讯作者：
Dong Zhao
中科院分区：
文献类型：
--
作者：
Jiayi Sun;Jun Liu;Zhangrong Jia;Dong Zhao
AIM
The lipoprotein-associated phospholipase A2(Lp-PLA2) level has been shown to be associated with the risk of clinical cardiovascular events. We aimed to investigate whether Lp-PLA2 is associated with the progression of subclinical atherosclerosis in the general population.
METHODS
The degree of carotid plaque and the maximal intima-media thickness(IMT) were measured twice over a 5-year interval in 913 participants 45 to 74 years of age at baseline in a cohort study. The associations between the plasma Lp-PLA2 activity and the progression of carotid plaque and changes in the IMT level were assessed according to sex after adjusting for traditional risk factors and the high-sensitivity C-reactive protein(hsCRP) level.
RESULTS
During the 5-year follow-up period, the progression of plaque was observed in 58.5% of men and 48.3% of women. The median maximal IMT level increased by 0.12 mm in men and 0.09 mm in women per year. The progression of plaque and changes in the IMT level increased according to the quartile of the Lp-PLA2 activity in men(p＜0.05 for trend), but not women. Following adjustment for traditional risk factors and the hsCRP level, the odds ratio for plaque progression associated with an increase in the Lp-PLA2 activity of one standard deviation was 1.28(95% CI=1.09-1.49, p=0.043) in men and 0.92(95% CI=0.78-1.08, p=0.273) in women. The regression coefficient for IMT progression was 0.003(p=0.004) in men and -0.001(p=0.166) in women after adjusting for the other factors.
CONCLUSIONS
The Lp-PLA2 level is associated with the progression of subclinical atherosclerosis in men. Lp-PLA2 may play an important role in the pathogenesis of atherosclerosis and be a potential target for the early prevention of cardiovascular disease.
登录
查看更多内容
影响因子：
16.2
作者：
Koska J;Saremi A;Bahn G;Yamashita S;Reaven PD;Veterans Affairs Diabetes Trial Investigators
通讯作者：
Veterans Affairs Diabetes Trial Investigators
DOI：
10.1161/01.atv.19.12.2909
发表时间：
1999-12-01
影响因子：
8.7
作者：
Häkkinen, T;Luoma, JS;Ylä-Herttuala, S
通讯作者：
Ylä-Herttuala, S
影响因子：
158.5
作者：
Packard, CJ;O'Reilly, DSJ;Lowe, GDO
通讯作者：
Lowe, GDO
影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB
DOI：
10.1161/01.atv.0000201289.83256.cf
发表时间：
2006-03-01
影响因子：
8.7
作者：
Kardys, I;Oei, HHS;Witteman, JCM
通讯作者：
Witteman, JCM