Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals.
Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals.
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DOI：
10.1002/ijc.23958
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发表时间：
2009-02-15
影响因子：
6.4
通讯作者：
Doelken, Gottfried
中科院分区：
文献类型：
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作者：
Schueler, Frank;Doelken, Lars;Hirt, Carsten;Kiefer, Thomas;Berg, Tobias;Fusch, Gerhard;Weitmann, K.;Hoffmann, W.;Fusch, Christoph;Janz, Siegfried;Rabkin, Charles S.;Doelken, Gottfried
T(14；18)易位是一种常见的遗传异常，可视为滤泡性淋巴瘤发病的早期步骤。健康个体中低水平循环t(14；18)阳性细胞作为克隆性淋巴瘤先兆或风险指标的意义尚不清楚。我们确定了715名健康个体中BCL2/IgH重排的年龄相关性患病率和频率，范围从新生儿到八旬和非老年人群。将这些结果与108例初发FL患者的循环t(14；18)阳性细胞数进行比较。在这个大样本中，bcl2/IGH连接的总体患病率为46%(327/715)。然而，这与年龄有着惊人的依赖关系。具体地说，在10岁以下的儿童中，没有人有可检测到的循环t(14；18)阳性细胞。在代表10-50岁的年龄组中，我们发现bcl2/IGH连接的患病率稳步上升，最高可达66%。50岁以上的人患病率没有进一步增加。40岁≥组bcl2/IgH基因平均频率(18~26×10−6)显著高于青年组(7~9×10−6)。4%(31/715)的人每25,000个外周血单核细胞(PBMNC)携带一个以上的t(14；18)阳性细胞。相比之下，108例III/IV期FL患者循环中t(14；18)阳性恶性FL细胞的中位数约为9200/100万PBMNC(范围7-100万)。这些发现将进一步提高对健康个体中t(14；18)阳性细胞作为发展为淋巴瘤前体的风险标记物的相关性的理解。
The t(14;18) translocation is a common genetic aberration that can be seen as an early step in pathogenesis of follicular lymphoma (FL). The significance of low level circulating t(14;18)-positive cells in healthy individuals as clonal lymphoma precursors or indicators of risk is still unclear. We determined the age dependent prevalence and frequency of BCL2/IgH rearrangements in 715 healthy individuals ranging from newborns to octo- and nonagenarians. These results were compared with number of circulating t(14;18)-positive cells in 108 FL patients at initial presentation. The overall prevalence of BCL2/IgH junctions in this large sample was 46% (327/715). However, there was a striking dependence upon age. Specifically, among individuals up to 10 years old, none had detectable circulating t(14;18)-positive cells. In the age groups representing 10–50 years old, we found a steady elevation in the prevalence of BCL2/IgH junctions up to a prevalence of 66%. Further increases of the prevalence in individuals older than 50 years were not seen. The mean frequency of BCL2/IgH junctions in healthy individuals ≥40 years (18–26 × 10−6) was significantly higher than in younger subjects (7–9 × 10−6). Four percent (31/715) of individuals carried more than one t(14;18)-positive cell per 25,000 peripheral blood mononuclear cells (PBMNCs). In comparison, 108 stage III/IV FL patients had a median number of circulating t(14;18)-positive malignant FL cells of about 9200/1 million PBMNCs (range 7–1,000,000). These findings will further improve the understanding of the relevance of t(14;18)-positive cells in healthy individuals as a risk marker toward the development into lymphoma precursors.
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DOI：
10.1084/jem.20061292
发表时间：
2006-10-30
期刊：
The Journal of experimental medicine
影响因子：
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作者：
Roulland S;Navarro JM;Grenot P;Milili M;Agopian J;Montpellier B;Gauduchon P;Lebailly P;Schiff C;Nadel B
通讯作者：
Nadel B
影响因子：
56.9
作者：
TSUJIMOTO, Y;FINGER, LR;CROCE, CM
通讯作者：
CROCE, CM
影响因子：
4.7
作者：
Fuscoe, JC;Setzer, RW;Moore, MM
通讯作者：
Moore, MM
影响因子：
20.3
作者：
Egle, A;Harris, AW;Cory, S
通讯作者：
Cory, S
DOI：
10.1007/bf01324255
发表时间：
2001-01-01
期刊：
SOZIAL-UND PRAVENTIVMEDIZIN
影响因子：
--
作者：
John, U;Greiner, B;Kessler, C
通讯作者：
Kessler, C