Tracing the evolution of the floral homeotic B- and C-function genes through genome synteny.
Tracing the evolution of the floral homeotic B- and C-function genes through genome synteny.
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DOI：
10.1093/molbev/msq156
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发表时间：
2010-11
影响因子：
10.7
通讯作者：
Davies B
中科院分区：
文献类型：
--
作者：
Causier B;Castillo R;Xue Y;Schwarz-Sommer Z;Davies B
花同源异型基因的进化已通过系统发育和功能研究进行了表征。通过比较物种之间的基因内容和顺序以确定调节基因的进化历史，可以加强这些研究。在这里，我们使用基于同线性的方法来追踪生殖器官规范所需的花 B 和 C 功能基因的进化。与之前的系统发育研究一致，我们表明 euAP3-TM6 分裂发生在单子叶植物和双子叶植物分化之后。拟南芥 TM6 和木瓜 euAP3 基因在各自的基因组中缺失，我们已经检测到这些基因丢失的位点。这些数据表明，TM6 或 euAP3 谱系基因可能会丢失，但不会损害花的发育。相比之下，PI对于男性生殖器官的发育至关重要；然而，与预测相反，复杂的基因组重排导致 PI 位点的同线性几乎完全崩溃。除了通过预测祖先位点显示 B 功能基因的进化之外，类似的重建还揭示了双子叶植物中 C 功能 AG 和 PLE 谱系的起源，并显示了与单子叶植物 C 功能基因的共同祖先。在我们的研究过程中，我们发现已测序的金鱼草基因组克隆中存在的转座元件（TE）限制了比较研究。对金鱼草数据的初步调查显示，基因丰富的区域包含异常高程度的不同类型的 TE，这将是未来基因组测序工作的重要考虑因素。
The evolution of the floral homeotic genes has been characterized using phylogenetic and functional studies. It is possible to enhance these studies by comparing gene content and order between species to determine the evolutionary history of the regulatory genes. Here, we use a synteny-based approach to trace the evolution of the floral B- and C-function genes that are required for specification of the reproductive organs. Consistent with previous phylogenetic studies, we show that the euAP3–TM6 split occurred after the monocots and dicots diverged. The Arabidopsis TM6 and papaya euAP3 genes are absent from the respective genomes, and we have detected loci from which these genes were lost. These data indicate that either the TM6 or the euAP3 lineage genes can be lost without detriment to flower development. In contrast, PI is essential for male reproductive organ development; yet, contrary to predictions, complex genomic rearrangements have resulted in almost complete breakdown of synteny at the PI locus. In addition to showing the evolution of B-function genes through the prediction of ancestral loci, similar reconstructions reveal the origins of the C-function AG and PLE lineages in dicots, and show the shared ancestry with the monocot C-function genes. During our studies, we found that transposable elements (TEs) present in sequenced Antirrhinum genomic clones limited comparative studies. A pilot survey of the Antirrhinum data revealed that gene-rich regions contain an unusually high degree of TEs of very varied types, which will be an important consideration for future genome sequencing efforts.
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影响因子：
64.5
作者：
JACK, T;BROCKMAN, LL;MEYEROWITZ, EM
通讯作者：
MEYEROWITZ, EM
DOI：
10.1073/pnas.97.13.7002
发表时间：
2000-06-20
影响因子：
11.1
作者：
Fedoroff, N
通讯作者：
Fedoroff, N
影响因子：
7.4
作者：
Caldwell, KS;Langridge, P;Powell, W
通讯作者：
Powell, W
影响因子：
64.8
作者：
Liljegren, SJ;Ditta, GS;Yanofsky, MF
通讯作者：
Yanofsky, MF
影响因子：
4.3
作者：
Ackerman, Christine M.;Yu, Qingyi;Ming, Ray
通讯作者：
Ming, Ray