Recent insights into humoral immunity targeting Plasmodium falciparum and Plasmodium vivax malaria.
Recent insights into humoral immunity targeting Plasmodium falciparum and Plasmodium vivax malaria.
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DOI：
10.1016/j.ijpara.2016.06.002
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发表时间：
2017-03
影响因子：
4
通讯作者：
Fowkes FJ
中科院分区：
文献类型：
--
作者：
Boyle MJ;Reiling L;Osier FH;Fowkes FJ
最近在控制疟疾方面的努力已导致疟疾发病率显著下降。然而，需要制定新的战略，以持续消除和根除疟疾，并实现世界卫生组织关于无疟疾世界的目标。高效疫苗的开发将有助于实现这一目标，并将通过全面了解针对恶性疟原虫和间日疟原虫疟疾的体液免疫反应来促进。需要新的工具来促进候选疫苗的鉴定和诱导功能性和保护性免疫的疫苗的开发。在这里，我们讨论了最近发表的研究结果，以及在2016年疟疾分子方法会议上发表的未发表的工作，这些工作强调了在疫苗开发背景下理解体液免疫反应的进展。重点包括更多地应用“组学”和“大数据”平台来识别候选疫苗，以及识别介导保护的抗体反应的新功能。这些战略和全球方法的应用将增加快速开发高效疫苗的可能性。
Recent efforts in malaria control have led to marked reductions in malaria incidence. However, new strategies are needed to sustain malaria elimination and eradication and achieve the World Health Organization goal of a malaria-free world. The development of highly effective vaccines would contribute to this goal and would be facilitated by a comprehensive understanding of humoral immune responses targeting Plasmodium falciparum and Plasmodium vivax malaria. New tools are required to facilitate the identification of vaccine candidates and the development of vaccines that induce functional and protective immunity. Here we discuss recent published findings, and unpublished work presented at the 2016 Molecular Approaches to Malaria conference, that highlight advancements in understanding humoral immune responses in the context of vaccine development. Highlights include the increased application of ‘omics’ and ‘Big data’ platforms to identify vaccine candidates, and the identification of novel functions of antibody responses that mediate protection. The application of these strategies and a global approach will increase the likelihood of rapid development of highly efficacious vaccines.
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影响因子：
9.3
作者：
Cutts JC;Powell R;Agius PA;Beeson JG;Simpson JA;Fowkes FJ
通讯作者：
Fowkes FJ
影响因子：
15.9
作者：
Chan, Jo-Anne;Howell, Katherine B.;Beeson, James G.
通讯作者：
Beeson, James G.
影响因子：
3
作者：
Diop, Fode;Richard, Vincent;Balde, Aissatou Toure
通讯作者：
Balde, Aissatou Toure
影响因子：
15.3
作者：
BOUHAROUNTAYOUN, H;OEUVRAY, C;DRUILHE, P
通讯作者：
DRUILHE, P
影响因子：
3.7
作者：
Ceesay, Serign J.;Casals-Pascual, Climent;Conway, David J.
通讯作者：
Conway, David J.