Immunological markers of Plasmodium vivax exposure and immunity: a systematic review and meta-analysis.
Immunological markers of Plasmodium vivax exposure and immunity: a systematic review and meta-analysis.
复制标题
DOI：
10.1186/s12916-014-0150-1
复制
发表时间：
2014-09-09
期刊：
影响因子：
9.3
通讯作者：
Fowkes FJ
中科院分区：
文献类型：
--
作者：
Cutts JC;Powell R;Agius PA;Beeson JG;Simpson JA;Fowkes FJ
鉴定与间日疟原虫感染和保护性免疫相关的间日疟原虫抗原特异性抗体是开发疟疾血清监测工具和疫苗的关键。间日疟原虫的抗体靶标可以通过对生活在间日疟原虫流行地区的个体的血清流行病学研究来鉴定，并且鉴于体外培养间日疟原虫的能力有限，这是一种重要的策略。已经有许多研究调查了间日疟原虫抗体应答与间日疟原虫感染之间的关联，但是没有标准化的结果来进行人群间的比较。我们对居住在间日疟原虫流行区的人群、横断面、病例对照和队列研究进行了系统回顾和荟萃分析。我们检索了6个数据库，确定了18项符合预定义的纳入和质量标准的研究，并检查了对间日疟原虫抗原的抗体应答与间日疟原虫疟疾之间的关联。大多数研究报告发表于南美洲（全部来自巴西），其余研究报告发表于亚太地区的不同地理区域。观察到估计值存在相当大的异质性，但对PvCSP、PvMSP-119、PvMSP-9 RIRII和PvAMA 1的IgG应答与地理上不同的人群中间日疟原虫感染几率增加相关。异质性的潜在来源包括研究设计、不同的传播强度和移民人群。观察到PvMSP-119、PvMSP-1 NT、PvMSP-3α和PvMSP-9 NT抗原抗体的保护性相关性，但仅在单一地理位置。本系统综述揭示了几种与活动性感染和保护性免疫相关的抗原特异性抗体，这些抗体可能是有用的生物标志物。然而，需要对其他抗原进行更多的研究，特别是队列研究，以增加保护性免疫的证据。需要更多代表不同地理区域的研究，包括不同的间日疟原虫地方性，以验证研究结果的普遍性，并为在疫苗和血清监测工具中使用间日疟原虫抗原提供坚实的证据基础。本文的在线版本（doi：10.1186/s12916-014-0150-1）包含补充材料，可供授权用户使用。
Identifying Plasmodium vivax antigen-specific antibodies associated with P. vivax infection and protective immunity is key to the development of serosurveillance tools and vaccines for malaria. Antibody targets of P. vivax can be identified by seroepidemiological studies of individuals living in P. vivax-endemic areas, and is an important strategy given the limited ability to culture P. vivax in vitro. There have been numerous studies investigating the association between P. vivax antibody responses and P. vivax infection, but there has been no standardization of results to enable comparisons across populations. We performed a systematic review with meta-analysis of population-based, cross-sectional, case–control, and cohort studies of individuals living in P. vivax-endemic areas. We searched 6 databases and identified 18 studies that met predefined inclusion and quality criteria, and examined the association between antibody responses to P. vivax antigens and P. vivax malaria. The majority of studies were published in South America (all from Brazil) and the rest from geographically diverse areas in the Asia-Pacific region. Considerable heterogeneity in estimates was observed, but IgG responses to PvCSP, PvMSP-119, PvMSP-9RIRII, and PvAMA1 were associated with increased odds of P. vivax infection in geographically diverse populations. Potential sources of heterogeneity included study design, different transmission intensities and transmigrant populations. Protective associations were observed for antibodies to PvMSP-119, PvMSP-1NT, PvMSP-3α and PvMSP-9NT antigens, but only in single geographical locations. This systematic review revealed several antigen-specific antibodies that were associated with active infection and protective immunity, which may be useful biomarkers. However, more studies are needed on additional antigens, particularly cohort studies to increase the body of evidence for protective immunity. More studies representing diverse geographical regions encompassing varying P. vivax endemicities are needed to validate the generalizability of the findings and to provide a solid evidence base for the use of P. vivax antigens in vaccines and serosurveillance tools. The online version of this article (doi:10.1186/s12916-014-0150-1) contains supplementary material, which is available to authorized users.
登录
查看更多内容
DOI：
10.4269/ajtmh.2011.09-0516
发表时间：
2011-02-01
影响因子：
3.3
作者：
Herrera, Socrates;Lucia Fernandez, Olga;Arevalo-Herrera, Myriam
通讯作者：
Arevalo-Herrera, Myriam
影响因子：
3
作者：
Fernandez-Becerra C;Sanz S;Brucet M;Stanisic DI;Alves FP;Camargo EP;Alonso PL;Mueller I;del Portillo HA
通讯作者：
del Portillo HA
影响因子：
2.4
作者：
Gomez, A.;Suarez, C. F.;Patarroyo, M. A.
通讯作者：
Patarroyo, M. A.
DOI：
10.1084/jem.172.1.379
发表时间：
1990-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Blackman MJ;Heidrich HG;Donachie S;McBride JS;Holder AA
通讯作者：
Holder AA
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N