Genotypic Analysis of Varicella-Zoster Virus and Its Seroprevalence in Finland
Genotypic Analysis of Varicella-Zoster Virus and Its Seroprevalence in Finland
复制标题
芬兰水痘带状疱疹病毒的基因型分析及其血清流行率
DOI：
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发表时间：
2007
影响因子：
--
通讯作者：
Vladimir N. Loparev
中科院分区：
文献类型：
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作者：
M. Koskiniemi;M. Lappalainen;D. S. Schmid;Elena N. Rubtcova;Vladimir N. Loparev
摘要：我们评估了芬兰人群中不同年龄组水痘带状疱疹病毒（VZV）的血清患病率，并从记录的水痘和带状疱疹病例中评估了VZV毒株的遗传特征。对1995年至1996年提交赫尔辛基大学病毒学系进行病毒学研究的2,842份血清样本进行了vzv特异性免疫球蛋白G的测定。从2名儿童患者和26名成人患者的水疱性病变中获得VZV基因分型标本。VZV的血清阳性率随年龄变化明显：≤2个月的儿童为45%，6 - 8个月的儿童为12.5%，10岁左右的儿童为bbb90 %，此后进入老年期趋于稳定。血清阳性率表明，在芬兰，与其他温带国家一样，原发性VZV感染通常发生在生命的头十年。对28份VZV dna阳性标本进行分析，鉴定VZV疫苗和野生型基因型。所有分析标本均为野生型和欧洲(E)基因型。
ABSTRACT We evaluated the seroprevalence of varicella-zoster virus (VZV) in the Finnish population among various age groups and genetically characterized VZV strains from documented cases of varicella and zoster. VZV-specific immunoglobulin G was measured in 2,842 serum samples that had been submitted for virological studies to the Department of Virology, University of Helsinki, from 1995 to 1996. Specimens for VZV genotyping were obtained from vesicular lesions from two pediatric patients and 26 adult patients. Seroprevalence to VZV varied markedly by age: 45% in children aged ≤2 months, 12.5% in children aged 6 to 8 months, and >90% in children near 10 years of age, plateauing thereafter into advanced age. The seroprevalence rates indicate that in Finland, as in other countries with temperate climates, primary VZV infection usually occurs during the first decade of life. Twenty-eight VZV DNA-positive specimens were analyzed to identify VZV vaccine and wild-type genotypes. All analyzed specimens were wild type and the European (E) genotype.
影响因子：
6.4
作者：
LaRussa, P;Steinberg, S;Gershon, A
通讯作者：
Gershon, A
水痘带状疱疹病毒的基因组分析：单个开放阅读框的引物。
DOI：
10.1016/s1386-6532(03)00073-8
发表时间：
2003
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
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作者：
Wagenaar,TR;Grose,C;Loparev,VN;Schmid,DS;Breuer,J
通讯作者：
Breuer,J