A conflict between spatial selection and evidence accumulation in area LIP.

A conflict between spatial selection and evidence accumulation in area LIP.
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DOI:
10.1038/s41467-022-32209-z
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发表时间:
2022-08-01
影响因子:
16.6
通讯作者:
--
中科院分区:
综合性期刊1区
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--
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侧顶叶内区(LIP)包含空间选择性神经元,帮助引导眼球运动,根据大量研究,通过积累有利于一种选择(例如,向左看)或另一种选择(向右看)的感官证据来实现这一目标。为了研究这种功能联系,我们训练两只猴子进行紧急动作辨别任务,在这项任务中,记录的神经元活动和受试者选择的演变可以逐毫秒跟踪。我们发现,虽然选择的准确性随着感官证据的增加而急剧增加,但与此同时,LIP选择信号变得越来越弱,就好像它阻碍了表现一样。这种效应与空间注意力在远离相关感官线索的不同位置的短暂部署是一致的。结果表明,LIP的空间选择与信息跳跃选择中的证据积累是分离的,甚至可能是冲突的。在灵长类动物区LIP中,目标选择和感觉证据的积累被认为是一个单一的过程。在这里,作者使用紧急选择任务来表明LIP中的空间选择不同于证据积累,甚至可能与证据积累相冲突。
The lateral intraparietal area (LIP) contains spatially selective neurons that help guide eye movements and, according to numerous studies, do so by accumulating sensory evidence in favor of one choice (e.g., look left) or another (look right). To examine this functional link, we trained two monkeys on an urgent motion discrimination task, a task with which the evolution of both the recorded neuronal activity and the subject’s choice can be tracked millisecond by millisecond. We found that while choice accuracy increased steeply with increasing sensory evidence, at the same time, the LIP selection signal became progressively weaker, as if it hindered performance. This effect was consistent with the transient deployment of spatial attention to disparate locations away from the relevant sensory cue. The results demonstrate that spatial selection in LIP is dissociable from, and may even conflict with, evidence accumulation during informed saccadic choices. In primate area LIP, target selection and the accumulation of sensory evidence are considered a single process. Here, the authors use urgent choice tasks to show that spatial selection in LIP is distinct from, and may even conflict with, evidence accumulation.
DOI: 10.1146/annurev-neuro-060909-152823
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