Exposure to Repetitive Head Impacts Is Associated With Corpus Callosum Microstructure and Plasma Total Tau in Former Professional American Football Players.
Exposure to Repetitive Head Impacts Is Associated With Corpus Callosum Microstructure and Plasma Total Tau in Former Professional American Football Players.
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DOI：
10.1002/jmri.27774
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Koerte IK
中科院分区：
文献类型：
--
作者：
Kochsiek J;O'Donnell LJ;Zhang F;Bonke EM;Sollmann N;Tripodis Y;Wiegand TLT;Kaufmann D;Umminger L;Di Biase MA;Kaufmann E;Schultz V;Alosco ML;Martin BM;Lin AP;Coleman MJ;Rathi Y;Pasternak O;Bouix S;Stern RA;Shenton ME;Koerte IK
Exposure to repetitive head impacts (RHI) is associated with an increased risk of later-life neurobehavioral dysregulation and neurodegenerative disease. The underlying pathomechanisms are largely unknown. To investigate whether RHI exposure is associated with later-life corpus callosum (CC) microstructure and whether CC microstructure is associated with plasma total tau and neuropsychological/neuropsychiatric functioning. Retrospective cohort study. 75 former professional American football players (age 55.2+/−8.0 years) with cognitive, behavioral, and mood symptoms. Diffusion-weighted echo-planar MRI (dMRI) at 3T. Subjects underwent dMRI, venous puncture, neuropsychological testing, and completed self-report measures of neurobehavioral dysregulation. RHI exposure was assessed using the Cumulative Head Impact Index (CHII). dMRI measures of CC microstructure, (i.e., free-water corrected fractional anisotropy (FA), trace, radial diffusivity (RD) and axial diffusivity (AD)), were extracted from seven segments of the CC (CC1–7), using a tractography clustering algorithm. Neuropsychological tests were selected: Trail Making Test Part A (TMT-A) and Part B (TMT-B), Controlled Oral Word Association Test (COWAT), Stroop Interference Test, the Behavioral Regulation Index (BRI) from the Behavior Rating Inventory of Executive Function, Adult version (BRIEF-A). dMRI metrics were tested for associations with RHI exposure, plasma total tau, neuropsychological performance, and neurobehavioral dysregulation using generalized linear models for repeated measures. RHI exposure was associated with increased AD of CC1 (correlation coefficient (r)=0.32, p<0.05) and with increased plasma total tau (r=0.34, p<0.05). AD of the anterior CC1 was associated with increased plasma total tau (CC1: r=0.30, p<0.05; CC2: r=0.29, p<0.05). Higher trace, AD, and RD of CC1 were associated with better performance (p<0.05) in TMT-A (trace, r=0.33; AD, r=0.31; and RD, r=0.28) and TMT-B (trace, r=0.31; RD, r=0.34). Higher FA and AD of CC2 were associated with better performance (p<0.05) in TMT-A (FA, r=0.36; AD, r=0.28)/TMT-B (FA, r=0.36; AD, r=0.27), COWAT (FA, r=0.3; AD, r=0.32)., and BRI (AD, r=0.2858). These results suggest an association between RHI exposure, CC microstructure, plasma total tau, and clinical functioning in former professional American football players.
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影响因子：
4.8
作者：
Michalicova A;Majerova P;Kovac A
通讯作者：
Kovac A
轴突结构的新发现的性别差异是体外创伤性轴突损伤的差异结果。
影响因子：
5.3
作者：
Dollé JP;Jaye A;Anderson SA;Ahmadzadeh H;Shenoy VB;Smith DH
通讯作者：
Smith DH
DOI：
10.1016/j.nicl.2017.06.027
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Liao R;Ning L;Chen Z;Rigolo L;Gong S;Pasternak O;Golby AJ;Rathi Y;O'Donnell LJ
通讯作者：
O'Donnell LJ
影响因子：
3.4
作者：
Kawata K;Steinfeldt JA;Huibregtse ME;Nowak MK;Macy JT;Kercher K;Rettke DJ;Shin A;Chen Z;Ejima K;Newman SD;Cheng H
通讯作者：
Cheng H
影响因子：
4
作者：
Banks, William A.;Kovac, Andrej;Zhang, Jing
通讯作者：
Zhang, Jing