Intestinal Barrier Dysfunction in Fatty Liver Disease: Roles of Microbiota, Mucosal Immune System, and Bile Acids.
Intestinal Barrier Dysfunction in Fatty Liver Disease: Roles of Microbiota, Mucosal Immune System, and Bile Acids.
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DOI：
10.1055/s-0042-1748037
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发表时间：
2022-05
影响因子：
4.2
通讯作者：
Raeman, Reben
中科院分区：
文献类型：
--
作者：
Gupta, Biki;Rai, Ravi;Oertel, Michael;Raeman, Reben
非酒精性脂肪性肝病（NAFLD）描述了一系列进行性肝病，从单纯性脂肪变性到脂肪性肝炎和纤维化。在全球范围内，NAFLD是与慢性肝病相关的发病率和死亡率的主要原因，NAFLD患者发生肝硬化和肝细胞癌的风险更高。虽然人们一致认为炎症在促进NAFLD进展中起着关键作用，但其潜在机制尚未得到很好的理解。最近的临床和实验证据表明，继发于饮食诱导的肠屏障损伤的肠道微生物抗原的肝移位增加可能在NAFLD中驱动肝脏炎症方面很重要。在这里，我们简要地回顾了各种内源性和外源性因素影响肠屏障和目前的进展，我们了解的细胞和分子机制，在NAFLD肠屏障功能障碍。
Nonalcoholic fatty liver disease (NAFLD) describes a spectrum of progressive liver diseases ranging from simple steatosis to steatohepatitis and fibrosis. Globally, NAFLD is the leading cause of morbidity and mortality associated with chronic liver disease, and NAFLD patients are at a higher risk of developing cirrhosis and hepatocellular carcinoma. While there is a consensus that inflammation plays a key role in promoting NAFLD progression, the underlying mechanisms are not well understood. Recent clinical and experimental evidence suggest that increased hepatic translocation of gut microbial antigens, secondary to diet-induced impairment of the intestinal barrier may be important in driving hepatic inflammation in NAFLD. Here, we briefly review various endogenous and exogenous factors influencing the intestinal barrier and present recent advances in our understanding of cellular and molecular mechanisms underlying intestinal barrier dysfunction in NAFLD.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
6.1
作者：
Bernstein, Carol;Holubec, Hana;Bhattacharyya, Achyut K.;Huy Nguyen;Payne, Claire M.;Zaitlin, Beryl;Bernstein, Harris
通讯作者：
Bernstein, Harris
DOI：
10.1084/jem.20011502
发表时间：
2002-01-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Campbell DJ;Butcher EC
通讯作者：
Butcher EC
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
DOI：
10.1073/pnas.1305923110
发表时间：
2013-06-25
影响因子：
11.1
作者：
Barr, Jeremy J.;Auro, Rita;Rohwer, Forest
通讯作者：
Rohwer, Forest