Efficacy of a foodlet-based multiple micronutrient supplement for preventing growth faltering, anemia, and micronutrient deficiency of infants: the four country IRIS trial pooled data analysis.
Efficacy of a foodlet-based multiple micronutrient supplement for preventing growth faltering, anemia, and micronutrient deficiency of infants: the four country IRIS trial pooled data analysis.
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基于食品的多种微量营养素补充剂预防婴儿生长迟缓、贫血和微量营养素缺乏的功效：四个国家 IRIS 试验汇总数据分析。
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
R. Gross
中科院分区：
文献类型：
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作者：
C. M. Smuts;C. Lombard;A. Benadé;M. Dhansay;J. Berger;L. T. Hop;G. L. D. Romaña;J. Untoro;E. Karyadi;J. Erhardt;R. Gross
世界各地的婴儿在生长迟缓和饮食从牛奶过渡到固体食物期间，饮食中通常缺乏多种微量营养素。在印度尼西亚、秘鲁、南非和越南进行了一项随机安慰剂对照试验，采用一种共同的方案来调查改善多种微量营养素的状况是否可以预防婴儿期生长迟缓和贫血。报告了4个国家的生长、贫血和微量营养素状况的汇总数据分析结果。共有1134名婴儿被随机分为4个治疗组，其中283名接受每日安慰剂（P），283名接受每周多种微量营养素补充剂（WMM），280名接受每日多种微量营养素（DMM）补充剂，288名接受每日铁（DI）补充剂。DMM组的体重增加明显更大，平均增长率为207 g/mo，而WMM组为192 g/mo，DI和P组为186 g/mo。身高增加无差异。DMM也是控制贫血和缺铁最有效的治疗方法，除了改善锌，视黄醇，生育酚和核黄素的状态。单独补充DI增加锌缺乏。基线时多种微量营养素缺乏症的患病率很高，贫血影响了大多数人，即使在补充6个月后也没有得到完全控制。这些积极的结果表明，需要更大的有效性试验，以检查如何提供补充剂在计划规模和估计成本效益。还应考虑增加食物中微量营养素的剂量。
Diets of infants across the world are commonly deficient in multiple micronutrients during the period of growth faltering and dietary transition from milk to solid foods. A randomized placebo controlled trial was carried out in Indonesia, Peru, South Africa, and Vietnam, using a common protocol to investigate whether improving status for multiple micronutrients prevented growth faltering and anemia during infancy. The results of the pooled data analysis of the 4 countries for growth, anemia, and micronutrient status are reported. A total of 1134 infants were randomized to 4 treatment groups, with 283 receiving a daily placebo (P), 283 receiving a weekly multiple micronutrient supplement (WMM), 280 received a daily multiple micronutrient (DMM) supplement, and 288 received daily iron (DI) supplements. The DMM group had a significantly greater weight gain, growing at an average rate of 207 g/mo compared with 192 g/mo for the WMM group, and 186 g/mo for the DI and P groups. There were no differences in height gain. DMM was also the most effective treatment for controlling anemia and iron deficiency, besides improving zinc, retinol, tocopherol, and riboflavin status. DI supplementation alone increased zinc deficiency. The prevalence of multiple micronutrient deficiencies at baseline was high, with anemia affecting the majority, and was not fully controlled even after 6 mo of supplementation. These positive results indicate the need for larger effectiveness trials to examine how to deliver supplements at the program scale and to estimate cost benefits. Consideration should also be given to increasing the dosages of micronutrients being delivered in the foodlets.
影响因子：
7.1
作者：
Brown, KH;Peerson, JM;Allen, LH
通讯作者：
Allen, LH