Prostate Cancer in African American Men: The Effect of Androgens and microRNAs on Epidermal Growth Factor Signaling.
Prostate Cancer in African American Men: The Effect of Androgens and microRNAs on Epidermal Growth Factor Signaling.
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DOI：
10.1007/s12672-016-0271-4
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发表时间：
2016-12
影响因子：
3
通讯作者：
Hinds TD Jr
中科院分区：
文献类型：
--
作者：
Nwaneri AC;McBeth L;Hinds TD Jr
前列腺癌（PC）是美国老年男性死亡的主要原因之一，仅次于肺癌。非裔美国人（AA）患PC的风险增加，与白人美国人（CA）相比，更有可能死于该疾病。AA和CA之间的染色体改变或遗传差异可能是PC进展中观察到的差异的原因。重要的是，雄激素受体（AR）或表皮生长因子受体（EGFR）的突变可能导致这种差异。目前的研究正在调查小核苷酸多态性（SNP）和microRNA（miRNAs）的作用，它们通过调节3′非翻译区（UTR）来影响受体的蛋白质翻译，从而可能促进PC的进展。然而，这些遗传差异尚未在两个种族群体之间的前列腺中得到充分探讨。本文将重点介绍EGFR信号通路以及SNPs和miRNA的参与，并将其与AA和CA男性PC中观察到的差异联系起来。了解这些差异，可以制定具体的预防和治疗策略，以针对前列腺癌的个性化药物。
Prostate cancer (PC) is one of the leading causes of mortality amongst elderly men in the USA and is second only to lung cancer. African Americans (AA) are at an increased risk of developing PC and are more likely to die from the disease in comparison to Caucasian Americans (CA). Chromosomal alterations or genetic differences between AA and CA may account for the variances observed in PC progression. Importantly, mutations in the androgen receptor (AR) or the epidermal growth factor receptor (EGFR) may contribute to the disparity. Current studies are investigating the role of small nucleotide polymorphisms (SNPs) and microRNAs (miRNAs), which affect protein translation of the receptors by regulation of the 3′ untranslated region (UTR), which may enhance the progression of PC. However, these genetic differences have not been fully explored in prostates between the two ethnic groups. This review will highlight the current studies on the EGFR signaling pathway as well as the involvement of SNPs and miRNAs and relate them to variances observed in PC of AA and CA men. With an understanding of these differences, specific preventive and therapeutic strategies may be developed to target personalized medicine for prostate carcinogenesis.
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