Chronic inflammation caused by lymphotoxin is lymphoid neogenesis.
Chronic inflammation caused by lymphotoxin is lymphoid neogenesis.
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由淋巴毒素引起的慢性炎症是淋巴的新生成。
DOI：
10.1084/jem.183.4.1461
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发表时间：
1996-04-01
影响因子：
15.3
通讯作者：
Ruddle, NH
中科院分区：
文献类型：
--
作者：
Kratz, A;CamposNeto, A;Hanson, MS;Ruddle, NH
In presenting a unifying concept for chronic inflammation and lymphoid organogenesis, we suggest that lymphotoxin's (LT, LT-alpha, TNF-beta) crucial role in these processes is pivotal and similar. Chronic inflammatory lesions that developed in the kidney and pancreas at the sites of transgene expression in rat insulin promoter-LT (RIP-LT) mice resembled lymph nodes with regard to cellular composition (T cells, B cells, plasma cells, and antigen-presenting cells), delineated T and B cell areas, primary and secondary follicles, characteristic morphologic and antigenic (ICAM-1, VCAM-1, MAdCAM-1, and PNAd) features of high endothelial venules, and ability to respond to antigen and undergo Ig class switching when obtained from mice immunized with SRBC. The vascular changes, with the exception of PNAd, appear to be the direct consequence of transgene derived LT expression, as they were also observed in RIP-LT mice lacking mature T and B cells. These data show that LT-induced chronic inflammation has the characteristics of organized lymphoid tissue.
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影响因子：
--
作者：
EIKELENBOOM, P;NASSY, JJJ;LANGEVOORT, HL
通讯作者：
LANGEVOORT, HL
DOI：
10.1073/pnas.91.11.5138
发表时间：
1994-05-24
影响因子：
11.1
作者：
GUERDER, S;PICARELLA, DE;FLAVELL, RA
通讯作者：
FLAVELL, RA
影响因子：
11.4
作者：
KEFFER, J;PROBERT, L;KOLLIAS, G
通讯作者：
KOLLIAS, G
影响因子：
15.9
作者：
HANNINEN, A;TAYLOR, C;MICHIE, SA
通讯作者：
MICHIE, SA
粘附分子的上调和共表达与中枢神经系统中的自身免疫性脱髓鞘相关。
影响因子：
15.3
作者：
Cannella, B;Cross, A H;Raine, C S
通讯作者：
Raine, C S