Antileishmanial metabolites from Geosmithia langdonii.
Antileishmanial metabolites from Geosmithia langdonii.
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DOI：
10.1021/np5000473
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发表时间：
2014-09-26
影响因子：
5.1
通讯作者：
Ross SA
中科院分区：
文献类型：
--
作者：
Malak LG;Ibrahim MA;Bishay DW;Abdel-baky AM;Moharram AM;Tekwani B;Cutler SJ;Ross SA
Antileishmanial bioassay guided fractionation of Geosmithia langdonii has resulted in the isolation and identification of two new compounds (1 and 2) together with 10 known compounds (3–12). The structures of the isolated metabolites were elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as mass spectrometry. The absolute configuration at C4, C5, and C6 of 2 was determined as R using a modified Mosher esterification method and NOESY correlations. The extracts and the isolated metabolites were evaluated for their antileishmanial activities. Compounds 3, 9, 11, and 12 were found to be active against Leishmania donovani with IC50 values of 6.9, 3.3, 8.5, and 9.2 μM, respectively, while compounds 1, 5, and 10 showed lower activities against L. donovani with IC50 values of 13.0, 47.3, and 34.0 μM, respectively.
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影响因子：
3.3
作者：
Uchida, R;Tomoda, H;Omura, S
通讯作者：
Omura, S
影响因子：
--
作者：
Kolarík, M;Kubátová, A;Srutka, P
通讯作者：
Srutka, P
影响因子：
3.5
作者：
Bharate, Sandip B.;Khan, Shabana I.;Singh, Inder Pal
通讯作者：
Singh, Inder Pal
影响因子：
5.1
作者：
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通讯作者：
CHILTON, WS
影响因子：
3.2
作者：
Hamid, R;Rotshteyn, Y;Bullock, P
通讯作者：
Bullock, P