Higher-order sensorimotor circuit of the brain's global network supports human consciousness.
Higher-order sensorimotor circuit of the brain's global network supports human consciousness.
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大脑全球网络的高阶感觉运动回路支持人类意识
DOI：
10.1016/j.neuroimage.2021.117850
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发表时间：
2021-05-01
期刊：
影响因子：
5.7
通讯作者：
Northoff, Georg
中科院分区：
文献类型：
--
作者：
Qin, Pengmin;Wu, Xuehai;Wu, Changwei;Wu, Hang;Zhang, Jun;Huang, Zirui;Weng, Xuchu;Zang, Di;Qi, Zengxin;Tang, Weijun;Hiromi, Tanikawa;Tan, Jiaxing;Tanabe, Sean;Fogel, Stuart;Hudetz, Anthony G.;Yang, Yihong;Stamatakis, Emmanuel A.;Mao, Ying;Northoff, Georg
关键词：
意识是心灵的决定性属性，其在大脑局部和全局活动中的确切神经关联尚不清楚。我们的目标是确定大脑全球功能网络中支持意识的关键节点。为此，我们利用了从三种不同状态的受试者中获得的大型fMRI静息状态数据集，其中意识要么保持（健康清醒状态），要么减少（n1 -睡眠状态和最低意识状态），要么丧失（n1 -睡眠状态，麻醉和无反应清醒状态）。我们纳入了一个独特的数据集，包括处于快速眼动睡眠状态（REM-sleep）的受试者，以测试在没有运动和感觉输入的情况下意识的存在。为了识别大脑全球功能网络中的关键节点，即枢纽，我们使用了基于roi的大脑网络功能连接的度中心性的图理论测量。我们发现各种高阶感觉和运动区域，包括辅助运动区、双侧边缘上回（下顶叶的一部分）、掌上/背前扣带皮层和左颞中回是重要的中枢，当意识缺失时，它们的中心性显著降低（所有组都观察到）。此外，我们观察到这些区域之间存在高度的功能连接，形成了一个感觉运动回路，该回路与不同组的意识水平显著相关，并且在快速眼动睡眠组中仍然存在。综上所述，我们证明形成高阶感觉运动整合电路的区域是支持大脑全球功能网络中意识的核心。这为意识障碍提供了新的、更有机制导向的治疗目标。
Consciousness is the defining property of the mind, whose exact neural correlates in the brain’s local and global activity remain unclear. We aimed to identify the critical nodes within the brain’s global functional network that support consciousness. To that end, we leveraged a large fMRI resting state dataset obtained from subjects in three distinct states where consciousness was either preserved (healthy awake state), reduced (N1-sleep state, and minimally conscious state), or lost (N3-sleep state, anesthesia, and unresponsive wakefulness state). We included a unique dataset of subjects in rapid eye movement sleep state (REM-sleep) to test for the presence of consciousness during the absence of movements and sensory input. To identify critical nodes, i.e., hubs, within the brain’s global functional network, we used a graph-theoretical measure of degree centrality conjoined with ROI-based functional connectivity of brain networks. We found that various higher-order sensory and motor regions including supplementary motor area, bilateral supramarginal gyrus (part of inferior parietal lobule), supragenual/dorsal anterior cingulate cortex, and left middle temporal gyrus were important hubs whose degree centrality was significantly reduced when consciousness remained absent (as observed in all groups). Additionally, we observed high degrees of functional connectivity among these regions, forming a sensorimotor circuit which was significantly correlated with levels of consciousness across the different groups and remained present in the REM-sleep group. Taken together, we demonstrate that regions forming a higher-order sensorimotor integration circuit are central in supporting consciousness within the brain’s global functional network. That offers novel and more mechanism-guided treatment targets for disorders of consciousness.
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影响因子：
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