Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.
Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.
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DOI：
10.1053/j.ajkd.2008.07.040
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Trischitta V
中科院分区：
文献类型：
--
作者：
De Cosmo S;Minenna A;Zhang YY;Thompson R;Miscio G;Vedovato M;Rauseo A;Saller A;Mastroianno S;Pellegrini F;Trevisan R;Fioretto P;Doria A;Trischitta V
Insulin resistance plays a role in diabetic kidney complications. The ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) (rs1044498) K121Q polymorphism has been associated with insulin resistance and related vascular complications among patients with type 2 diabetes (T2D), in many although not all studies. This study investigated whether the ENPP1 Q121 variant modulates the risk of reduced GFR in T2D. Cross-sectional study. Two Diabetes Units from Italy (Gargano e Padua) and one from the US (Boston) recruited a total of 1392 patients with T2D. The ENPP1 Q121 variant. Estimated glomerular filtration rate (eGFR) from serum creatinine, urinary albumin excretion, blood pressure, HbA1c, Triglycerides, Total cholesterol, HDL-Cholesterol Reduced GFR levels (i.e. eGFR <60 ml/min/1.73m2). In the Gargano and Boston populations, according to dominant model of inheritance, Q121 carriers (i.e. individual with either KQ or QQ genotype) had an increased risk of reduced GFR: ORs=1.69 (95%CI 1.1–2.6) and 1.50 (95%CI 1.0–2.2), respectively. In the Padua set the association was in the same direction but didn’t reach a formal statistical significance (OR=1.77, 95%CI 0.7–4.5). When the three studies were pooled, Q121 carriers showed and increased risk of reduced GFR (OR=1.58, 95%CI 1.2–2.1, p=0.002). Also pooled mean differences of absolute GFR values were different across genotype groups with Q121 carriers showing lower GFR, as compared to KK individuals (p=0.04). p values not approaching a genome-wide level of significance. Our data suggest that patients with T2D carrying the ENPP1 Q121 variant are at increased risk of reduced GFR.
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