Endometriosis in the Mouse: Challenges and Progress Toward a 'Best Fit' Murine Model.
Endometriosis in the Mouse: Challenges and Progress Toward a 'Best Fit' Murine Model.
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DOI：
10.3389/fphys.2021.806574
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发表时间：
2021
影响因子：
4
通讯作者：
Burney RO
中科院分区：
文献类型：
--
作者：
Burns KA;Pearson AM;Slack JL;Por ED;Scribner AN;Eti NA;Burney RO
子宫内膜异位症是一种常见的妇科疾病，与盆腔疼痛和不孕症有关，其特征是子宫内膜组织通过逆行月经移位到盆腔内种植和生长。小鼠是一种分子注释良好且具有成本效益的物种，用于在治疗发现管道中模拟人类疾病。然而，作为一个非月经的物种与一个封闭的输卵管卵巢交界处，小鼠提出了固有的挑战，作为临床前模型子宫内膜异位症的研究。在过去的三十年里，许多小鼠模型的子宫内膜异位症已被描述不同程度的忠实于概括的基本病理生理特征的人类疾病。我们对同行评议文献进行了检索，以确定描述使用子宫内膜异位症小鼠模型进行临床前研究的出版物。根据目前对子宫内膜异位症病理生理学的理解，根据一组理想的模型参数对每个模型进行了审查。评估的参数包括移植方法、周期阶段和移植组织类型、受体免疫/卵巢状态、移植迭代时间表和纵向病变评估选项。虽然挑战仍然存在，但最近的模型已经采用了创新的技术方法，如体内荧光成像和新型激素制剂，以克服小鼠解剖学和生理学带来的独特挑战。这些模型提供了显着的优势，病变的发展和读数对一个高保真的小鼠模型，在子宫内膜异位症的转化研究。
Endometriosis is a prevalent gynecologic condition associated with pelvic pain and infertility characterized by the implantation and growth of endometrial tissue displaced into the pelvis via retrograde menstruation. The mouse is a molecularly well-annotated and cost-efficient species for modeling human disease in the therapeutic discovery pipeline. However, as a non-menstrual species with a closed tubo-ovarian junction, the mouse poses inherent challenges as a preclinical model for endometriosis research. Over the past three decades, numerous murine models of endometriosis have been described with varying degrees of fidelity in recapitulating the essential pathophysiologic features of the human disease. We conducted a search of the peer-reviewed literature to identify publications describing preclinical research using a murine model of endometriosis. Each model was reviewed according to a panel of ideal model parameters founded on the current understanding of endometriosis pathophysiology. Evaluated parameters included method of transplantation, cycle phase and type of tissue transplanted, recipient immune/ovarian status, iterative schedule of transplantation, and option for longitudinal lesion assessment. Though challenges remain, more recent models have incorporated innovative technical approaches such as in vivo fluorescence imaging and novel hormonal preparations to overcome the unique challenges posed by murine anatomy and physiology. These models offer significant advantages in lesion development and readout toward a high-fidelity mouse model for translational research in endometriosis.
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影响因子：
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作者：
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