Inflammation and thrombosis biomarkers and incident frailty in postmenopausal women.
Inflammation and thrombosis biomarkers and incident frailty in postmenopausal women.
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DOI：
10.1016/j.amjmed.2009.04.016
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发表时间：
2009-10
影响因子：
5.9
通讯作者：
LaCroix, Andrea Z.
中科院分区：
文献类型：
--
作者：
Reiner, Alexander P.;Aragaki, Aaron K.;Gray, Shelly L.;Wactawski-Wende, Jean;Cauley, Jane A.;Cochrane, Barbara B.;Kooperberg, Charles L.;Woods, Nancy F.;LaCroix, Andrea Z.
The immune and blood coagulation systems have been implicated in the pathophysiology of the geriatric syndrome of frailty, but limited prospective data examining the relationship of clotting/inflammation biomarkers to risk of incident frailty exists. This prospective analysis was derived from a nested case-control study within the Women's Health Initiative. Among women 65-79 years free of frailty at enrollment, we randomly selected 900 incident cases from those developing frailty within 3 years; 900 non-frail controls were individually matched on age, ethnicity, and blood collection date. Biomarkers assessed for risk of incident frailty included fibrinogen, factor VIII, D-dimer, C-reactive protein (CRP), interleukin (IL)-6, and tissue plasminogen activator (t-PA). When examined by quartiles in multivariable adjusted models, higher D-dimer and t-PA levels were each associated with increased risk of frailty (p trend=0.04). Relative to the lowest quartile, the odds ratios for frailty compared to the upper quartile were 1.52 [95% confidence interval (CI), 1.05-2.22] for t-PA and 1.57 (95% CI, 1.11-2.22) for D-dimer. For women having high t-PA and high D-dimer compared to women having lower levels of both biomarkers, the odds of frailty was 2.20 (1.29-3.75). There was little evidence for association between coagulation factor VIII, fibrinogen, CRP, or IL-6 levels and incident frailty. This prospective analysis supports the role of markers of fibrin turnover and fibrinolysis as independent predictors of incident frailty in post-menopausal women.
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DOI：
10.1111/j.1532-5415.2008.01673.x
发表时间：
2008-05-01
影响因子：
6.3
作者：
De Fanis, Umberto;Wang, George C.;Leng, Sean X.
通讯作者：
Leng, Sean X.
DOI：
10.1093/gerona/56.3.m158
发表时间：
2001-03-01
影响因子：
5.1
作者：
Newman, AB;Gottdiener, JS;Fried, LP
通讯作者：
Fried, LP
影响因子：
5.9
作者：
Cohen, HJ;Harris, T;Pieper, CF
通讯作者：
Pieper, CF
DOI：
10.1093/gerona/62.1.79
发表时间：
2007-01-01
影响因子：
5.1
作者：
Folsom, Aaron R.;Boland, Lori L.;Walston, Jeremy D.
通讯作者：
Walston, Jeremy D.
影响因子：
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作者：
Walston, J;McBurnie, MA;Fried, LP
通讯作者：
Fried, LP