Comparing polyelectrolyte multilayer-coated PMMA microfluidic devices and glass microchips for electrophoretic separations.
Comparing polyelectrolyte multilayer-coated PMMA microfluidic devices and glass microchips for electrophoretic separations.
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DOI：
10.1002/elps.200900403
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发表时间：
2009-12
期刊：
影响因子：
2.9
通讯作者：
Heineman, William R.
中科院分区：
文献类型：
--
作者：
Currie, Christa A.;Shim, Joon Sub;Lee, Se Hwan;Ahn, Chong;Limbach, Patrick A.;Halsall, H. Brian;Heineman, William R.
微流控领域一直在推动微芯片系统从更昂贵的玻璃微芯片转移到更便宜的聚合物微芯片。在这里，我们研究使用聚电解质多层膜(PEM)作为聚甲基丙烯酸甲酯(PMMA)微芯片的涂层系统，以提高其功能。采用聚二烯丙基二甲基氯化铵(PDAD)和聚苯乙烯磺酸(PSS)层层沉积的方法制备了多层膜体系。探索了涂覆PMMA微芯片的实用方面。通过EOF测量对多层膜的堆积过程进行了监测，并考察了膜的稳定性。比较了PEM-PMMA微芯片与标准玻璃微芯片和PEM-玻璃微芯片在电渗流和分离两种荧光染料方面的性能。还介绍了PMMA芯片多层涂层工艺发展过程中的几个关键发现。研究发现，通过精心制备，可以制备出性能与标准玻璃微芯片相当--在某些情况下甚至更好--的PEM-PMMA微芯片。
There is a continuing drive in microfluidics to transfer microchip systems from the more expensive glass microchips to cheaper polymer microchips. Here, we investigate using polyelectrolyte multilayers (PEM) as a coating system for poly (methylmethacrylate) (PMMA) microchips to improve their functionality. The multilayer system was prepared by layer-on-layer depositon of poly (diallydimethylammonium) chloride (PDAD) and polystyrene sulfonate (PSS). Practical aspects of coating PMMA microchips were explored. The multilayer buildup process was monitored using EOF measurements, and the stability of the PEM was investigated. The performance of the PEM-PMMA microchip was compared to those of a standard glass microchip and a PEM-glass microchip in terms of electroosmotic flow and separating two fluorescent dyes. Several key findings in the development of the multilayer coating procedure for PMMA chips are also presented. It was found that, with careful preparation, a PEM-PMMA microchip can be prepared that has properties comparable - and in some cases superior - to those of a standard glass microchip.
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