Exposure to perfluoroalkyl substances and associations with serum thyroid hormones in a remote population of Alaska Natives.
Exposure to perfluoroalkyl substances and associations with serum thyroid hormones in a remote population of Alaska Natives.
复制标题
DOI：
10.1016/j.envres.2018.06.014
复制
发表时间：
2018-10
影响因子：
8.3
通讯作者：
Carpenter DO
中科院分区：
文献类型：
--
作者：
Byrne SC;Miller P;Seguinot-Medina S;Waghiyi V;Buck CL;von Hippel FA;Carpenter DO
已知全氟烷基物质（PFAS）会在北极传统食用动物体内积累，北极土著人民可能通过食用自给性动物而接触到PFAS。PFAS被怀疑会破坏人类甲状腺激素的稳态。本研究的目的是评估阿拉斯加原住民偏远人群血清PFASs和甲状腺功能之间的关系。从阿拉斯加州圣劳伦斯岛的85名个体中收集血清样品。定量血清样本中13种PFAS以及游离和总甲状腺素（T4）、游离和总三碘甲状腺原氨酸（T3）和促甲状腺激素（TSH）的浓度。PFASs和甲状腺激素的循环浓度之间的关系进行了评估，使用多元线性回归拟合广义估计方程。几种PFAS，包括全氟辛酸（PFOA）和全氟壬酸（PFNA），正相关的TSH浓度单独建模时。在采用全氟辛烷磺酸 * 性别交互项的模型中，全氟辛烷磺酸和全氟萘甲酸与游离三碘甲状腺原氨酸显著相关，全氟萘甲酸与总三碘甲状腺原氨酸显著相关;这些关联表明，男性与全氟辛烷磺酸存在负面关联，女性与全氟萘甲酸存在正面关联。PFAS与游离或总T4浓度无显著相关性。血清PFAS与阿拉斯加土著偏远人群的循环甲状腺激素浓度相关。PFAS暴露对甲状腺激素稳态的影响可能因性别而异。
Perfluoroalkyl substances (PFASs) are known to accumulate in traditional food animals of the Arctic, and arctic indigenous peoples may be exposed via consumption of subsistence- harvested animals. PFASs are suspected of disrupting thyroid hormone homeostasis in humans. The aim of this study is to assess the relationship between serum PFASs and thyroid function in a remote population of Alaska Natives. Serum samples were collected from 85 individuals from St. Lawrence Island, Alaska. The concentrations of 13 PFASs, as well as free and total thyroxine (T4), free and total triiodothyronine (T3), and thyrotropin (TSH) were quantified in serum samples. The relationships between circulating concentrations of PFASs and thyroid hormones were assessed using multiple linear regression fit with generalized estimating equations. Several PFASs, including perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA), were positively associated with TSH concentrations when modeled individually. PFOS and PFNA were significantly associated with free T3 and PFNA was significantly associated with total T3 in models with PFAS*sex interactive terms; these associations suggested negative associations in men and positive associations in women. PFASs were not significantly associated with concentrations of free or total T4. Serum PFASs are associated with circulating thyroid hormone concentrations in a remote population of Alaska Natives. The effects of PFAS exposure on thyroid hormone homeostasis may differ between sexes.
登录
查看更多内容
DOI：
10.1016/j.envpol.2017.08.020
发表时间：
2017-12
期刊：
Environmental pollution (Barking, Essex : 1987)
影响因子：
--
作者：
Byrne S;Seguinot-Medina S;Miller P;Waghiyi V;von Hippel FA;Buck CL;Carpenter DO
通讯作者：
Carpenter DO
影响因子：
5.8
作者：
Imaizumi, M;Akahoshi, M;Eguchi, K
通讯作者：
Eguchi, K
影响因子：
11.4
作者：
Ellis, DA;Martin, JW;Wallington, TJ
通讯作者：
Wallington, TJ
影响因子：
5.8
作者：
Bremner, Alexandra P.;Feddema, Peter;Walsh, John P.
通讯作者：
Walsh, John P.
DOI：
10.1080/15287394.2015.1037412
发表时间：
2015
期刊：
Journal of toxicology and environmental health. Part A
影响因子：
--
作者：
Byrne S;Miller P;Waghiyi V;Buck CL;von Hippel FA;Carpenter DO
通讯作者：
Carpenter DO