Amplicon Remodeling and Genomic Mutations Drive Population Dynamics after Segmental Amplification.
Amplicon Remodeling and Genomic Mutations Drive Population Dynamics after Segmental Amplification.
复制标题
扩增子重塑和基因组突变驱动分段扩增后的群体动态。
DOI：
10.1093/molbev/msab289
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发表时间：
2022-01-07
影响因子：
10.7
通讯作者：
Copley SD
中科院分区：
文献类型：
--
作者：
Morgenthaler AB;Fritts RK;Copley SD
新的酶通常通过编码具有混杂活性的酶的基因的复制和分化而进化，这些酶在面对环境机遇或挑战时变得重要。增加被选择基因的拷贝数的扩增通常扩增许多周围的基因。这些共扩增基因的额外拷贝必须在新酶的进化过程中或之后被移除。在这里，我们报告说，扩增子重塑可以开始，甚至在突变发生在基因选择。扩增子重塑和基因组中其他地方的突变间接增加了适应性，导致复杂的种群动态，导致出现了通过不同机制改善适应性的克隆。在这项工作中，两个最成功的克隆之一经历了两次扩增子重塑，只留下四个共同扩增的基因围绕着被选择的基因。另一个克隆中的扩增子重塑导致从基因组中删除111个基因，这在这些选择条件下是可以接受的解决方案，但在其他环境条件下肯定会损害适应性。
New enzymes often evolve by duplication and divergence of genes encoding enzymes with promiscuous activities that have become important in the face of environmental opportunities or challenges. Amplifications that increase the copy number of the gene under selection commonly amplify many surrounding genes. Extra copies of these coamplified genes must be removed, either during or after evolution of a new enzyme. Here we report that amplicon remodeling can begin even before mutations occur in the gene under selection. Amplicon remodeling and mutations elsewhere in the genome that indirectly increase fitness result in complex population dynamics, leading to emergence of clones that have improved fitness by different mechanisms. In this work, one of the two most successful clones had undergone two episodes of amplicon remodeling, leaving only four coamplified genes surrounding the gene under selection. Amplicon remodeling in the other clone resulted in removal of 111 genes from the genome, an acceptable solution under these selection conditions, but one that would certainly impair fitness under other environmental conditions.
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影响因子：
3.2
作者：
Brochet, Mathieu;Couve, Elisabeth;Glaser, Philippe
通讯作者：
Glaser, Philippe
影响因子：
9.2
作者：
Lipinski, Kendra J.;Farslow, James C.;Fitzpatrick, Kelly A.;Lynch, Michael;Katju, Vaishali;Bergthorsson, Ulfar
通讯作者：
Bergthorsson, Ulfar
影响因子：
3.2
作者：
Kershner, Jamie P.;McLoughlin, Sean Yu;Copley, Shelley D.
通讯作者：
Copley, Shelley D.
DOI：
10.1073/pnas.0608309103
发表时间：
2006-11-14
影响因子：
11.1
作者：
Kugelberg, Elisabeth;Kofoid, Eric;Roth, John R.
通讯作者：
Roth, John R.
影响因子：
4.4
作者：
Bu L;Katju V
通讯作者：
Katju V