Prospective research on infants with mild encephalopathy: the PRIME study.
Prospective research on infants with mild encephalopathy: the PRIME study.
复制标题
DOI：
10.1038/jp.2017.164
复制
发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Sant'Anna G
中科院分区：
文献类型：
--
作者：
Prempunpong C;Chalak LF;Garfinkle J;Shah B;Kalra V;Rollins N;Boyle R;Nguyen KA;Mir I;Pappas A;Montaldo P;Thayyil S;Sánchez PJ;Shankaran S;Laptook AR;Sant'Anna G
确定出生时有缺氧缺血证据并在<6 h龄时被归类为轻度新生儿脑病（NE）的婴儿的短期结局。前瞻性多中心研究。轻度NE定义为改良Sarnat评分中≥ 1分异常。主要结局为出院时早期振幅整合脑电图（aEEG）或癫痫发作、脑磁共振成像（MRI）或神经系统检查异常。共有54/63例（86%）入组婴儿具有主要结局组成部分的数据，其中28/54例（52%）异常：不连续aEEG（n = 4）、MRI（n = 9）和出院检查（n = 22）。异常音调和/或不完全的摩罗是最常见的发现。MRI异常仅限于大脑皮质，但两名婴儿有基底节和/或丘脑受累。18至24个月的随访正在进行中。观察到具有异常结局的轻度NE婴儿的比例大于预期。未来的研究应评估轻度NE神经保护的安全性和有效性。
To determine short-term outcomes of infants with evidence of hypoxia–ischemia at birth and classified as mild neonatal encephalopathy (NE) at <6 h of age. Prospective multicenter study. Mild NE was defined as ⩾ 1 abnormal category in modified Sarnat score. Primary outcome was any abnormality on early amplitude integrated electroencephalogram (aEEG) or seizures, abnormal brain magnetic resonance imaging (MRI) or neurological exam at discharge. A total of 54/63 (86%) of enrolled infants had data on components of the primary outcome, which was abnormal in 28/54 (52%): discontinuous aEEG (n = 4), MRI (n = 9) and discharge exam (n = 22). Abnormal tone and/or incomplete Moro were the most common findings. MRI abnormalities were confined to cerebral cortex but two infants had basal ganglia and/or thalamus involvement. The 18 to 24 months follow-up is ongoing. A larger than expected proportion of mild NE infants with abnormal outcomes was observed. Future research should evaluate safety and efficacy of neuroprotection for mild NE.
登录
查看更多内容
影响因子：
8
作者：
Murray, Deirdre M.;Boylan, Geraldine B.;Connolly, Sean
通讯作者：
Connolly, Sean
影响因子：
48
作者：
Rutherford, Mary;Ramenghi, Luca A.;Edwards, A. David;Brocklehurst, Peter;Halliday, Henry;Levene, Malcolm;Strohm, Brenda;Thoresen, Marianne;Whitelaw, Andrew;Azzopardi, Denis
通讯作者：
Azzopardi, Denis
影响因子：
5.1
作者：
Glass, Hannah C.;Glidden, David;Jeremy, Rita J.;Barkovich, A. James;Ferriero, Donna M.;Miller, Steven P.
通讯作者：
Miller, Steven P.
影响因子：
5.1
作者：
Akula, Vishnu Priya;Joe, Priscilla;Van Meurs, Krisa
通讯作者：
Van Meurs, Krisa
影响因子：
3.8
作者：
Kharoshankaya, Liudmila;Stevenson, Nathan J.;Boylan, Geraldine B.
通讯作者：
Boylan, Geraldine B.