Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury.
Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury.
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DOI：
10.1016/j.jpeds.2009.03.040
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发表时间：
2009-09
影响因子：
5.1
通讯作者：
Miller, Steven P.
中科院分区：
文献类型：
--
作者：
Glass, Hannah C.;Glidden, David;Jeremy, Rita J.;Barkovich, A. James;Ferriero, Donna M.;Miller, Steven P.
确定新生儿癫痫发作是否与缺氧缺血婴儿的神经发育结局相关，与磁共振成像（MRI）上脑损伤的存在和严重程度无关。我们采用多元回归分析来研究临床新生儿癫痫发作及其治疗对77例有缺氧缺血性脑损伤风险的足月新生儿神经发育的独立影响。前瞻性记录临床癫痫发作，并使用高分辨率新生儿MRI测量脑损伤的严重程度。结果测量是韦氏学龄前和小学智力量表修订版的全量表智商（FSIQ）和四年时的神经运动评分。在控制MRI损伤的严重程度后，新生儿癫痫发作的儿童的运动和认知结果比没有癫痫发作的儿童差。不同程度的癫痫发作对FSIQ的影响程度不同，重度癫痫发作的儿童FSIQ低于轻中度癫痫发作的儿童（P < 0.0001）。新生儿窒息时临床癫痫发作与神经发育不良相关，与缺氧缺血性脑损伤的严重程度无关。随机对照试验是必不可少的，以确定是否在癫痫治疗的差异可以改善结果。
To determine whether neonatal seizures are associated with neurodevelopmental outcome in infants with hypoxia-ischemia, independent of the presence and severity of brain injury on magnetic resonance imaging (MRI). We used multivariate regression to examine the independent effect of clinical neonatal seizures and their treatment on neurodevelopment in 77 term newborns at risk for hypoxic-ischemic brain injury. Clinical seizures were recorded prospectively, and high-resolution newborn MRI was used to measure the severity of brain injury. The outcome measure was full-scale intelligence quotient (FSIQ) of the Wechsler Preschool and Primary Scale of Intelligence-Revised and the neuromotor score at four years. After controlling for severity of injury on MRI, children with neonatal seizures had worse motor and cognitive outcomes than those without seizures. The magnitude of effect varied with seizure severity: children with severe seizures had a lower FSIQ than those with mild/moderate seizures (P < 0.0001). Clinical neonatal seizures in the setting of birth asphyxia are associated with worse neurodevelopmental outcome, independent of the severity of hypoxic-ischemic brain injury. Randomized controlled trials are essential to determine whether differences in seizure treatment can improve outcome.
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影响因子：
9.9
作者：
Boylan, GB;Rennie, JM;Binnie, CD
通讯作者：
Binnie, CD
影响因子：
11.2
作者：
Holmes, GL;Gairsa, JL;Ben-Ari, Y
通讯作者：
Ben-Ari, Y
影响因子：
5.3
作者：
McCabe, BK;Silveira, DC;Holmes, GL
通讯作者：
Holmes, GL
DOI：
10.1111/j.1471-0528.1987.tb03121.x
发表时间：
1987-05-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
MINCHOM, P;NISWANDER, K;WILLIAMS, G
通讯作者：
WILLIAMS, G
影响因子：
3.4
作者：
Lynch, M;Sayin, Ü;Sutula, T
通讯作者：
Sutula, T