Circulating adiponectin and leptin and risk of overall and aggressive prostate cancer: a systematic review and meta-analysis.
Circulating adiponectin and leptin and risk of overall and aggressive prostate cancer: a systematic review and meta-analysis.
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DOI：
10.1038/s41598-020-79345-4
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发表时间：
2021-01-11
影响因子：
4.6
通讯作者：
Martin RM
中科院分区：
文献类型：
--
作者：
Burton AJ;Gilbert R;Tilling K;Langdon R;Donovan JL;Holly JMP;Martin RM
肥胖与晚期、复发性和致命性前列腺癌的风险增加有关。脂肪因子可能介导这种关系。我们对瘦素和脂联素与总体和侵袭性前列腺癌的关系进行了系统回顾和荟萃分析。系统检索了截至2017年4月1日的文献数据库。推导并合并脂联素或瘦素水平每增加2.5单位的对数比值比（OR）。所有分析均按研究类型（横断面/前瞻性）分层。共检索到746篇文献，确定了34项合格研究，其中31项可纳入荟萃分析。瘦素与总体前列腺癌的相关性并不一致（合并OR 1.00，95%CI 0.98-1.02，每增加2.5 ng/ml，前瞻性研究OR 0.97，95%CI 0.95-0.99，横断面研究OR 1.19，95%CI 1.13-1.26），并且有弱证据表明与侵袭性疾病呈正相关（OR 1.03，95%CI 1.00-1.06）。也有微弱的证据表明脂联素与总体前列腺癌呈小的负相关（OR 0.96，95%CI 0.93-0.99，每增加2.5 μg/ml），但与侵袭性疾病相关的证据较少（OR 0.98，95%CI 0.94-1.01）。任何影响的幅度都很小，因此单独的循环脂联素或瘦素水平不太可能成为风险或预后的有用生物标志物。
Obesity is associated with an increased risk of advanced, recurrent and fatal prostate cancer. Adipokines may mediate this relationship. We conducted a systematic review and meta-analysis of associations of leptin and adiponectin with overall and aggressive prostate cancer. Bibliographic databases were systematically searched up to 1st April 2017. Log Odds Ratios (ORs) per 2.5 unit increase in adiponectin or leptin levels were derived and pooled. All analyses were stratified by study type (cross-sectional/prospective). 746 papers were retrieved, 34 eligible studies identified, 31 of these could be included in the meta-analysis. Leptin was not consistently associated with overall prostate cancer (pooled OR 1.00, 95%CI 0.98–1.02, per 2.5 ng/ml increase, prospective study OR 0.97, 95%CI 0.95–0.99, cross-sectional study OR 1.19, 95%CI 1.13–1.26) and there was weak evidence of a positive association with aggressive disease (OR 1.03, 95%CI 1.00–1.06). There was also weak evidence of a small inverse association of adiponectin with overall prostate cancer (OR 0.96, 95%CI 0.93–0.99, per 2.5 µg/ml increase), but less evidence of an association with aggressive disease (OR 0.98, 95%CI 0.94–1.01). The magnitude of any effects are small, therefore levels of circulating adiponectin or leptin alone are unlikely to be useful biomarkers of risk or prognosis.
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影响因子：
--
作者：
Fryczkowski M;Bułdak RJ;Hejmo T;Kukla M;Żwirska-Korczala K
通讯作者：
Żwirska-Korczala K
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
DOI：
10.1007/s10552-015-0654-9
发表时间：
2015-11
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Davies NM;Gaunt TR;Lewis SJ;Holly J;Donovan JL;Hamdy FC;Kemp JP;Eeles R;Easton D;Kote-Jarai Z;Al Olama AA;Benlloch S;Muir K;Giles GG;Wiklund F;Gronberg H;Haiman CA;Schleutker J;Nordestgaard BG;Travis RC;Neal D;Pashayan N;Khaw KT;Stanford JL;Blot WJ;Thibodeau S;Maier C;Kibel AS;Cybulski C;Cannon-Albright L;Brenner H;Park J;Kaneva R;Batra J;Teixeira MR;Pandha H;PRACTICAL consortium;Lathrop M;Smith GD;Martin RM
通讯作者：
Martin RM
影响因子：
7.4
作者：
Dardeno, Tina A.;Chou, Sharon H.;Moon, Hyun-Seuk;Chamberland, John P.;Fiorenza, Christina G.;Mantzoros, Christos S.
通讯作者：
Mantzoros, Christos S.
影响因子：
3.8
作者：
Flower, L;Ahuja, RH;Mohamed-Ali, V
通讯作者：
Mohamed-Ali, V