Circulating Levels of Omentin, Leptin, VEGF, and HGF and Their Clinical Relevance with PSA Marker in Prostate Cancer.
Circulating Levels of Omentin, Leptin, VEGF, and HGF and Their Clinical Relevance with PSA Marker in Prostate Cancer.
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DOI：
10.1155/2018/3852401
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Żwirska-Korczala K
中科院分区：
文献类型：
--
作者：
Fryczkowski M;Bułdak RJ;Hejmo T;Kukla M;Żwirska-Korczala K
前列腺癌（PCa）在欧洲发病率居第一位，在波兰居第二位。前列腺癌的危险因素包括：遗传负荷、肥胖、富含脂肪的饮食、高脂血症和暴露于雄激素。前列腺特异性抗原（PSA）水平可能在前列腺癌或其他前列腺疾病中升高。脂肪组织分泌脂肪细胞因子，增加癌症发展和转移的风险。 本研究旨在探讨前列腺增生（BPH）和前列腺癌（PCa）患者血清中PSA、脂肪细胞因子（网膜素、瘦素、肝细胞生长因子（HGF）和血管内皮生长因子（VEGF））的循环水平之间的关系。 为了研究的目的，对40名诊断为BPH的患者和40名诊断为PCa的患者进行了评估。采用酶联免疫吸附试验（EIA）测定网膜素、瘦素、HGF和VEGF的浓度。 前列腺癌组的PSA水平显著高于BPH组（18.2 vs 9 ng/mL，p < 0.01），而BPH组的前列腺体积显著高于前列腺癌组（39.1 vs 31.1 cm 3，p = 0.02）。前列腺癌组的HGF、VEGF、网膜素和瘦素浓度显著高于BPH组（分别为359.5 vs 294.9 pg/mL，p = 0.04; 179.3 vs 127.3 pg/mL，p < 0.01; 478.8 vs 408.3 ng/mL，p = 0.01; 15.7 vs 11.2 ng/mL，p = 0.02）。多元Logistic回归分析显示，只有网膜素和PSA水平是研究对象中PCa的独立预测因子。 与PSA相比，PSA水平和网膜素水平可能是PCa有价值的临床意义的标志物。
Prostate cancer (PCa) is the first in terms of occurrence in Europe and second in Poland. The PCa risk factors include: genetic load, obesity, diet rich in fat, hypertriglyceridemia, and exposure to androgens. The prostate-specific antigen (PSA) level may be elevated in prostate cancer or other prostate disorders. Fat tissue secretes adipocytokines, which increase the risk of cancer development and metastasis. The aims of the study were to investigate the relationship between circulating levels of PSA, adipocytokines: omentin, leptin, hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF) in serum obtained from patients with benign prostate hyperplasia (BPH) and prostate cancer (PCa). Forty patients diagnosed with BPH and forty diagnosed with PCa were assessed for the purpose of the study. The concentrations of omentin, leptin, HGF, and VEGF were determined using enzyme-linked immunosorbent assays (EIA). PSA level was significantly higher in the PCa group than in BPH (18.2 versus 9 ng/mL, p < 0.01), while volume of prostate gland was significantly higher in the BPH group than in PCa (39.1 versus 31.1 cm3, p = 0.02). HGF, VEGF, omentin, and leptin concentrations were significantly higher in PCa group than in BPH (359.5 versus 294.9 pg/mL, p = 0.04; 179.3 versus 127.3 pg/mL, p < 0.01; 478.8 versus 408.3 ng/mL, p = 0.01; 15.7 versus 11.2 ng/mL, p = 0.02, resp.). The multiple logistic regression analysis demonstrated that only omentin and PSA levels were independent predictors of PCa in studied subjects. PSA level as well as the level of omentin may be valuable markers of PCa with clinical significance, when compared to PSA.
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DOI：
10.1016/j.bbacli.2016.10.002
发表时间：
2016-12
期刊：
BBA clinical
影响因子：
--
作者：
Karabulut, Senem;Afsar, Cigdem Usul;Karabulut, Mehmet;Alis, Halil;Bozkurt, Mehmet Abdussamet;Aydogan, Fatma;Serilmez, Murat;Tas, Faruk
通讯作者：
Tas, Faruk
影响因子：
3.3
作者：
Kim, Hye-Jung;Kang, Un-Beom;Lee, Cheolju
通讯作者：
Lee, Cheolju
影响因子：
45.3
作者：
Kitahara, Cari M.;Berndt, Sonja I.;Huang, Wen-Yi
通讯作者：
Huang, Wen-Yi
影响因子：
10.3
作者：
Kelly, Scott P.;Graubard, Barry I.;Cook, Michael B.
通讯作者：
Cook, Michael B.
影响因子：
11.2
作者：
Aleksandrova, Krasimira;di Giuseppe, Romina;Boeing, Heiner
通讯作者：
Boeing, Heiner