Persons with Parkinson's disease exhibit decreased neuromuscular complexity during gait.
Persons with Parkinson's disease exhibit decreased neuromuscular complexity during gait.
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DOI：
10.1016/j.clinph.2013.02.006
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Hass CJ
中科院分区：
文献类型：
--
作者：
Rodriguez KL;Roemmich RT;Cam B;Fregly BJ;Hass CJ
个体肌肉激活模式可以由中枢神经系统构建的运动模块控制，以简化运动控制。本研究比较了帕金森病 (PD) 患者和神经健康老年人 (HOA) 的步态模块化控制，并研究了帕金森病患者的模块化组织与步态参数之间的关系。 15 名特发性 PD 患者和 14 名 HOA 患者参与。当参与者在仪器跑步机上以自己喜欢的步行速度行走十分钟时，对双侧八块腿部肌肉进行肌电图记录。非负矩阵分解技术分解肌电信号，识别模块的数量和性质，这些模块占跑步机行走期间肌肉激活变化的 95%。一般来说，与 HOA 相比，PD 跑步机行走期间重建肌肉激活模式所需的模块更少 (p<.05)。 PD 中膝屈肌和踝跖屈肌组织的控制得到简化。 PD 中的激活时间发生了改变，而肌肉权重不受影响。神经肌肉控制的简化与帕金森病患者步行速度的降低有关。 PD 中步态的神经肌肉控制被简化，并可能导致该人群的步态缺陷。未来帕金森病运动康复的研究应考虑神经肌肉的复杂性，以最大限度地提高干预效果。
Individual muscle activation patterns may be controlled by motor modules constructed by the central nervous system to simplify motor control. This study compared modular control of gait between persons with Parkinson’s disease (PD) and neurologically-healthy older adults (HOA) and investigated relationships between modular organization and gait parameters in persons with PD. Fifteen persons with idiopathic PD and fourteen HOA participated. Electromyographic recordings were made from eight leg muscles bilaterally while participants walked at their preferred walking speed for ten minutes on an instrumented treadmill. Non-negative matrix factorization techniques decomposed the electromyographic signals, identifying the number and nature of modules accounting for 95% of variability in muscle activations during treadmill walking. Generally, fewer modules were required to reconstruct muscle activation patterns during treadmill walking in PD compared to HOA (p<.05). Control of knee flexor and ankle plantarflexor musculature was simplified in PD. Activation timing was altered in PD while muscle weightings were unaffected. Simplified neuromuscular control was related to decreased walking speed in PD. Neuromuscular control of gait is simplified in PD and may contribute to gait deficits in this population. Future studies of locomotor rehabilitation in PD should consider neuromuscular complexity to maximize intervention effectiveness.
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