Pachymetric mapping with Fourier-domain optical coherence tomography.
Pachymetric mapping with Fourier-domain optical coherence tomography.
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DOI：
10.1016/j.jcrs.2009.11.016
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发表时间：
2010-05
影响因子：
2.8
通讯作者：
Huang, David
中科院分区：
文献类型：
--
作者：
Li, Yan;Tang, Maolong;Zhang, Xinbo;Salaroli, Camila H.;Ramos, Jose L.;Huang, David
为了评价傅立叶域光学相干断层扫描(FD-OCT)角膜测厚图的可重复性，并将其与超声角膜测厚仪和OrbScan II的测量结果进行比较。扫描的中心要么是角膜顶点，要么是瞳孔。用合并标准差(SD)评估中心和中心周围MAP扇区的可重复性。通过配对t检验、Pearson相关分析和Bland-Altman分析，将OCT测量的CCT与B超和OrbScan II测量的CCT进行比较。在所有扇区(P<；0.035)，瞳孔中心(SD：中心1.3mSD，中心周长1.83.8μm)的重复性都好于顶点中心中心点(1.7μm中心点，中心周长2.4m5.7μm)。OCT、B超和OrbScan II(声学系数0.92)测量的CCT值分别为536.9±27.0、556.6±30.5和537.2±32.6μm。OCT测得的角膜厚度明显小于超声测得的角膜厚度(P=0.007，平均差值−为19.7μm，95%符合限为-40.4~0.9μm)，但与OrbScan II测值无显著差异(P=0.2637，平均差值为-0.3μm，95%符合限为-2 4.0~2 3.5μm)。OCT CCT与B超和OrbScan II的相关性良好(皮尔逊相关系数分别为0.940和0.934)。FD-OCT的角膜厚度标测重复性高。以瞳孔为中心的扫描重复性好于以角膜顶点为中心的扫描。超声测厚仪、FD-OCT和OrbScan II不能互换使用来评估角膜厚度。
To evaluate the repeatability of Fourier-domain optical coherence tomography (FD-OCT) pachymetric mapping and compare OCT central corneal thickness (CCT) measurements with those of ultrasound pachymetry and Orbscan II. Doheny Eye Institute, University of Southern California, Los Angeles, CA An FD-OCT system (RTVue-CAM, Optovue Inc., Fremont, CA) was used to map the corneal thickness of fifty normal participants. The scans were centered on either the corneal vertex or pupil. The repeatability of central and pericentral map sectors were assessed by pooled standard deviation (SD). The CCT measured by OCT was compared with those measured by ultrasound and Orbscan II by paired t-test, Pearson correlation, and Bland-Altman analysis. Pupil centration (SD: 1.3 μm central, 1.8-3.8 μm pericentral) provided better repeatability than vertex centration (1.7 μm central, 2.4-5.7 μm pericentral) in all sectors (P<0.035). The CCT measured by OCT, ultrasound, and Orbscan II (acoustic factor 0.92) was 536.9±27.0, 556.6±30.5, and 537.2±32.6 μm, respectively. The CCT measured by OCT was significantly thinner than ultrasound pachymetric readings (P=0.007, mean difference −19.7 μm, 95% limits of agreement -40.4 to 0.9 μm) but not those of Orbscan II (P=0.2637, mean difference -0.3 μm, 95% limits of agreement -24.0 to 23.5 μm). The OCT CCT correlated well with those of ultrasound and Orbscan II (Pearson r = 0.940 and 0.934, respectively). Pachymetric mapping with FD-OCT was highly repeatable. The repeatability was better with pupil-centered scans than with corneal vertex-centered scans. Ultrasound pachymetry, FD-OCT and Orbscan II should not be used interchangeably for the assessment of corneal thickness.
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影响因子：
13.7
作者：
Li, Emmy Y. M.;Mohamed, Shaheeda;Lam, Dennis S. C.
通讯作者：
Lam, Dennis S. C.
影响因子：
13.7
作者：
Li, Y;Shekhar, R;Huang, D
通讯作者：
Huang, D
影响因子：
13.7
作者：
Prisant, O;Calderon, N;Hoang-Xuan, T
通讯作者：
Hoang-Xuan, T
圆锥角膜诊断具有光学相干断层扫描映射映射。
影响因子：
13.7
作者：
Li Y;Meisler DM;Tang M;Lu AT;Thakrar V;Reiser BJ;Huang D
通讯作者：
Huang D
影响因子：
4.4
作者：
Mohamed, Shaheeda;Lee, Gary K. Y.;Lam, Dennis S. C.
通讯作者：
Lam, Dennis S. C.