Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME study.
Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME study.
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DOI：
10.1289/ehp.1307261
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发表时间：
2014-05
影响因子：
10.4
通讯作者：
Lanphear BP
中科院分区：
文献类型：
--
作者：
Braun JM;Kalkbrenner AE;Just AC;Yolton K;Calafat AM;Sjödin A;Hauser R;Webster GM;Chen A;Lanphear BP
背景资料：内分泌干扰物（EDCs）可能参与自闭症谱系障碍的病因，但在EDCs的混合物中识别相关化学物质是困难的。目的：我们的目标是确定与自闭症行为相关的妊娠EDC暴露。研究方法：我们测量了HOME（健康结果和环境措施）研究（辛辛那提，OH）中175名孕妇血液或尿液样本中8种邻苯二甲酸酯代谢物、双酚A、25种多氯联苯（PCB）、6种有机氯农药、8种溴化阻燃剂和4种全氟烷基物质的浓度。当孩子4岁和5岁时，母亲完成了社会反应量表（SRS），这是一种衡量自闭症行为的方法。我们使用两阶段分层分析检查了52个EDCs和SRS评分之间的混杂调整关联，以解释相关EDCs的重复测量和混杂。结果：大多数EDC与SRS评分的绝对差异可忽略不计（≤ 1.5）。血清中多溴二苯醚-28（PBDE-28）（β = 2.5; 95% CI：-0.6，5.6）或反式九甲草胺（β = 4.1; 95% CI：0.8-7.3）浓度每增加2个标准差，与更多的自闭症行为相关。相比之下，在检测到PCB-178（β = -3.0; 95% CI：-6.3，0.2）、β-六氯环己烷（β = -3.3; 95% CI：-6.1，0.5）或PBDE-85（β = -3.2; 95% CI：-5.9，0.5）浓度的妇女所生子女中，观察到的自闭症行为较少。全氟辛酸酯（PFOA）浓度的增加也与自闭症行为的减少相关（β = -2.0; 95%CI：-4.4，0.4）。结论：在这个队列中，一些内分泌干扰物与自闭症行为有关，但我们的样本量有限，使我们无法排除与零关联的化学物质。全氟辛酸、β-六氯环己烷、多氯联苯-178、多溴二苯醚-28、多溴二苯醚-85和反式九甲草胺作为可能与儿童自闭症行为有关的因素，值得进一步审查。引文：Braun JM，Kalkbrenner AE，Just AC，Yolton K，卡拉法特AM，Sjödin A，豪瑟R，韦伯斯特GM，Chen A，Lanphear BP. 2014. 4岁和5岁儿童暴露于内分泌干扰化学物质和相互的社会，重复和刻板行为：HOME研究环境健康展望122：513-520; http：dx.doi.org/10.1289/ehp.1307261
Background: Endocrine-disrupting chemicals (EDCs) may be involved in the etiology of autism spectrum disorders, but identifying relevant chemicals within mixtures of EDCs is difficult. Objective: Our goal was to identify gestational EDC exposures associated with autistic behaviors. Methods: We measured the concentrations of 8 phthalate metabolites, bisphenol A, 25 polychlorinated biphenyls (PCBs), 6 organochlorine pesticides, 8 brominated flame retardants, and 4 perfluoroalkyl substances in blood or urine samples from 175 pregnant women in the HOME (Health Outcomes and Measures of the Environment) Study (Cincinnati, OH). When children were 4 and 5 years old, mothers completed the Social Responsiveness Scale (SRS), a measure of autistic behaviors. We examined confounder-adjusted associations between 52 EDCs and SRS scores using a two-stage hierarchical analysis to account for repeated measures and confounding by correlated EDCs. Results: Most of the EDCs were associated with negligible absolute differences in SRS scores (≤ 1.5). Each 2-SD increase in serum concentrations of polybrominated diphenyl ether-28 (PBDE-28) (β = 2.5; 95% CI: –0.6, 5.6) or trans-nonachlor (β = 4.1; 95% CI: 0.8–7.3) was associated with more autistic behaviors. In contrast, fewer autistic behaviors were observed among children born to women with detectable versus nondetectable concentrations of PCB-178 (β = –3.0; 95% CI: –6.3, 0.2), β-hexachlorocyclohexane (β = –3.3; 95% CI: –6.1, –0.5), or PBDE-85 (β = –3.2; 95% CI: –5.9, –0.5). Increasing perfluorooctanoate (PFOA) concentrations were also associated with fewer autistic behaviors (β = –2.0; 95% CI: –4.4, 0.4). Conclusions: Some EDCs were associated with autistic behaviors in this cohort, but our modest sample size precludes us from dismissing chemicals with null associations. PFOA, β-hexachlorocyclohexane, PCB-178, PBDE-28, PBDE-85, and trans-nonachlor deserve additional scrutiny as factors that may be associated with childhood autistic behaviors. Citation: Braun JM, Kalkbrenner AE, Just AC, Yolton K, Calafat AM, Sjödin A, Hauser R, Webster GM, Chen A, Lanphear BP. 2014. Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME Study. Environ Health Perspect 122:513–520; http://dx.doi.org/10.1289/ehp.1307261
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影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
2
作者：
Gelman, Andrew
通讯作者：
Gelman, Andrew
影响因子：
5
作者：
Cole, Stephen R.;Hernan, Miguel A.
通讯作者：
Hernan, Miguel A.
影响因子：
10.4
作者：
Dingemans MM;van den Berg M;Westerink RH
通讯作者：
Westerink RH
DOI：
10.1080/00039896.1994.9934409
发表时间：
1994-01-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
GREENLAND, S;POOLE, C
通讯作者：
POOLE, C