Role of Organic Cation Transporter 3 and Plasma Membrane Monoamine Transporter in the Rewarding Properties and Locomotor Sensitizing Effects of Amphetamine in Male andFemale Mice.
Role of Organic Cation Transporter 3 and Plasma Membrane Monoamine Transporter in the Rewarding Properties and Locomotor Sensitizing Effects of Amphetamine in Male andFemale Mice.
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DOI：
10.3390/ijms222413420
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发表时间：
2021-12-14
影响因子：
5.6
通讯作者：
Daws LC
中科院分区：
文献类型：
--
作者：
Clauss NJ;Koek W;Daws LC
由于缺乏有效的治疗以及在精神兴奋剂成瘾和过量方面存在基于性别的差异，有必要对苯丙胺类兴奋剂滥用相关影响的潜在机制进行进一步调查。摄取-2转运蛋白，如有机阳离子转运蛋白3（OCT 3）和质膜单胺转运蛋白（PMAT），较少研究的刺激药物的作用的潜在目标，已知在单胺能神经传递中发挥作用。我们的目标是研究OCT 3和PMAT在介导安非他明（1 mg/kg）诱导的条件性位置偏爱（CPP）和对运动刺激作用的敏感性中的作用，在雄性和雌性中，使用药理学，decyphase-22（D22; 0.1 mg/kg，OCT 3和PMAT的阻断剂）和遗传学（组成性OCT 3和PMAT敲除（−/−）小鼠）方法。我们的研究结果表明，OCT 3是必要的CPP的发展，以安非他明在男性，而在女性中，PMAT是必要的D22的能力，以防止CPP的发展，以安非他明。OCT 3和PMAT似乎是重要的发展致敏的运动兴奋剂作用的安非他明在女性和PMAT在男性。综上所述，这些研究结果支持一个重要的，性别依赖性的作用OCT 3和PMAT的奖励和运动兴奋剂的安非他明的影响。
A lack of effective treatment and sex-based disparities in psychostimulant addiction and overdose warrant further investigation into mechanisms underlying the abuse-related effects of amphetamine-like stimulants. Uptake-2 transporters such as organic cation transporter 3 (OCT3) and plasma membrane monoamine transporter (PMAT), lesser studied potential targets for the actions of stimulant drugs, are known to play a role in monoaminergic neurotransmission. Our goal was to examine the roles of OCT3 and PMAT in mediating amphetamine (1 mg/kg)-induced conditioned place preference (CPP) and sensitization to its locomotor stimulant effects, in males and females, using pharmacological, decynium-22 (D22; 0.1 mg/kg, a blocker of OCT3 and PMAT) and genetic (constitutive OCT3 and PMAT knockout (−/−) mice) approaches. Our results show that OCT3 is necessary for the development of CPP to amphetamine in males, whereas in females, PMAT is necessary for the ability of D22 to prevent the development of CPP to amphetamine. Both OCT3 and PMAT appear to be important for development of sensitization to the locomotor stimulant effect of amphetamine in females, and PMAT in males. Taken together, these findings support an important, sex-dependent role of OCT3 and PMAT in the rewarding and locomotor stimulant effects of amphetamine.
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DOI：
10.1111/j.1530-0277.2006.00215.x
发表时间：
2006-10-01
影响因子：
3.2
作者：
Aoyama, Nagisa;Takahashi, Nagahide;Ozaki, Norio
通讯作者：
Ozaki, Norio
影响因子：
4.2
作者：
Cano, Manuel;Huang, Ying
通讯作者：
Huang, Ying
影响因子：
4.7
作者：
Fleckenstein AE;Volz TJ;Hanson GR
通讯作者：
Hanson GR
影响因子：
4.8
作者：
Engel, K;Zhou, MY;Wang, J
通讯作者：
Wang, J
DOI：
10.1073/pnas.0800466105
发表时间：
2008-12-02
影响因子：
11.1
作者：
Baganz, Nicole L.;Horton, Rebecca E.;Daws, Lynette C.
通讯作者：
Daws, Lynette C.