D-serine treatment reduces cocaine-primed reinstatement in rats following extended access to cocaine self-administration.
D-serine treatment reduces cocaine-primed reinstatement in rats following extended access to cocaine self-administration.
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DOI：
10.1016/j.neuroscience.2010.06.006
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发表时间：
2010-09-01
期刊：
影响因子：
3.3
通讯作者：
Wagner, J. J.
中科院分区：
文献类型：
--
作者：
Kelamangalath, L.;Wagner, J. J.
吸毒成瘾最棘手的特点是复吸率高，即使在长期戒断吸毒之后也是如此。有证据表明，允许大鼠长期接触可卡因自我给药会导致这些动物的行为特征与人类成瘾的发展一致。在目前的研究中，大鼠被允许在总共22个每日阶段中自我施用可卡因，其中最后7个是持续时间为6小时的长期访问（LGA）阶段。在重新引入吸毒环境和CS或可卡因的非偶然启动后，对已熄灭和戒断受试者组的觅药行为的恢复进行评估。将三个单独的大鼠组用盐水或D-丝氨酸（100 mg/kg i. p.）在每次消退训练期之前或之后立即施用。生理盐水处理的LGA大鼠抵抗消退训练的影响，以减少非偶然引发的CS或可卡因寻求药物的行为的恢复。相比之下，在疗程之前或之后立即用D-丝氨酸治疗导致消退训练减少可卡因引发的寻求药物行为恢复的能力显著增强。这些结果表明，D-丝氨酸可以加强LgA大鼠的消退学习的巩固，因此是一个有前途的治疗药物沿着行为治疗可卡因成瘾。
The most intractable feature of drug addiction is the high rate of relapse, even following extended periods of abstinence from drug-taking. Evidence suggests that allowing rats extended access to cocaine self-administration leads to behavioral characteristics in these animals that are consistent with the development of addiction in humans. In the current study, rats were allowed to self-administer cocaine over a total of 22 daily sessions, the final 7 of which were long-access (LgA) sessions of 6 hours duration. Assessments of reinstatement of drug-seeking behavior were made following reintroduction to the drug-taking environment and noncontingent priming with either CS or cocaine in both extinguished and abstinent subject groups. Three separate groups of rats were treated with either saline or D-serine (100mg/kg i.p.) administered 2 hrs prior to, or immediately following, each extinction training session. Saline-treated LgA rats were resistant to the effects of extinction training to reduce noncontingent priming of reinstatement of drug-seeking behavior with either CS or cocaine. In contrast, treatment with D-serine either before or immediately following the sessions resulted in a significant enhancement in the ability of extinction training to reduce cocaine-primed reinstatement of drug-seeking behavior. These results suggest that D-serine can act to enhance the consolidation of extinction learning in LgA rats, and is therefore a promising adjunctive agent along with behavioral therapy for the treatment of cocaine addiction.
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DOI：
10.1124/jpet.107.122861
发表时间：
2007-09-01
影响因子：
3.5
作者：
Knackstedt, Lori A.;Kalivas, Peter W.
通讯作者：
Kalivas, Peter W.
影响因子：
7.6
作者：
Duffy, Steven;Labrie, Viviane;Roder, John C.
通讯作者：
Roder, John C.
影响因子：
2.7
作者：
Karasawa, Jun-Ichi;Hashimoto, Kenji;Chaki, Shigeyuki
通讯作者：
Chaki, Shigeyuki
影响因子：
3.4
作者：
JAFFE, JH;CASCELLA, NG;SHERER, MA
通讯作者：
SHERER, MA
影响因子：
3.4
作者：
Mantsch, JR;Yuferov, V;Kreek, MJ
通讯作者：
Kreek, MJ