Neural mechanisms underlying the processing of emotional stimuli in individuals with depression: An ALE meta-analysis study
Neural mechanisms underlying the processing of emotional stimuli in individuals with depression: An ALE meta-analysis study
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抑郁症患者情绪刺激处理的神经机制：一项 ALE 荟萃分析研究
DOI：
10.1016/j.psychres.2022.114598
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发表时间：
2022-05
影响因子：
11.3
通讯作者：
Liu Zhiyuan
中科院分区：
文献类型：
--
作者：
Zhang Zhenyu;Huang Pujiang;Li Shuyu;Liu Zhiyu;Zhang Jiayao;Li Ya'nan;Liu Zhiyuan
抑郁症是导致生理问题和自杀的主要原因。以往的研究表明，抑郁症患者对积极和消极的情绪刺激都表现出异常的处理。然而，抑郁症患者在处理积极和消极情绪刺激时大脑活动的共同和不同模式仍然存在争议。目前的荟萃分析研究使用激活似然估计方法，在21项功能磁共振成像研究中调查这些问题。结果显示，与非抑郁个体相比，抑郁个体在正性情绪刺激时，扣带回前部、额中回和额中回的激活程度更高;在负性情绪刺激时，扣带回前部、额下回和额中回的激活程度更高。此外，我们发现MFG在抑郁症患者中始终被激活，无论情绪刺激的类型如何。然而，我们没有发现抑郁症患者的积极和消极情绪刺激之间的大脑活动模式。我们的研究结果表明，积极和消极的情绪刺激处理共享相同的认知控制相关的大脑区域在个体抑郁症。
Depression is the leading cause of physiological problems and suicide. Previous studies have indicated that individuals with depression show abnormal processing of both positive and negative emotional stimuli. However, the common and distinct patterns of brain activity during the processing of positive and negative emotional stimuli in individuals with depression remain controversial. The current meta-analysis study used the activation likelihood estimation method to investigate these issues across 21 functional magnetic resonance imaging studies. Results revealed that, compared with individuals without depression, individuals with depression showed higher activation in the anterior cingulate gyrus, insula, and middle frontal gyrus (MFG) for positive emotional stimuli and higher activation in the MFG, inferior frontal gyrus, and insula for negative emotional stimuli. Moreover, we identified that the MFG was consistently activated in individuals with depression regardless of the type of emotional stimuli. However, we did not find distinct patterns of brain activity between positive and negative emotional stimuli in individuals with depression. Our results demonstrated that both positive and negative emotional stimuli processing shares the same cognitive control-related brain regions in individuals with depression.
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影响因子：
4.8
作者：
Eickhoff, Simon B.;Laird, Angela R.;Grefkes, Christian;Wang, Ling E.;Zilles, Karl;Fox, Peter T.
通讯作者：
Fox, Peter T.
影响因子：
3.8
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.2
作者：
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影响因子：
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作者：
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