PAINFUL PERIUNGUAL TELANGIECTASIAS IN A PATIENT WITH ACQUIRED IMMUNODEFICIENCY SYNDROME
PAINFUL PERIUNGUAL TELANGIECTASIAS IN A PATIENT WITH ACQUIRED IMMUNODEFICIENCY SYNDROME
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获得性免疫缺陷综合征患者的疼痛性甲周毛细血管扩张症
DOI：
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发表时间：
1995
影响因子：
3.6
通讯作者：
J. Rodenas
中科院分区：
文献类型：
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作者：
PEDRO RUIZ‐AVILA;J. Tercedor;E. Fuentes;A. Villar;J. Rodenas
一名 36 岁男性，有肠外药物滥用史，2 年前被诊断患有获得性免疫缺陷综合症 (AIDS)，目前正在接受肠外葡聚糖治疗内脏利什曼病。患者主诉甲周有疼痛性红斑病变；暴露于热或冷时疼痛不会恶化或减轻。体格检查显示甲周红斑伴多发性毛细血管扩张（图1）。对甲周皮肤进行活组织检查。组织学研究显示真皮浅层扩张的血管数量增加，血管壁坚硬，内皮正常（图 2）。特异性染色未能检测到耐酸酒精杆菌、利什曼原虫或真菌。近端甲襞的毛细血管显微镜检查显示弥漫性扩张的毛细血管，没有无血管区域或出血。抗核抗体滴度呈阴性，血清肌酸和磷酸激酶水平以及肌电图正常。甲周病灶未见变化，直至3个月后患者因卡氏肺囊虫感染死亡。
A 36-year-old man with a history of parenteral drug abuse and who was diagnosed with acquired immunodeficiency syndrome (AIDS) 2 years previously, was being treated for visceral leishmaniasis with parenteral glucantime. The patient complained of painful erythematous periungual lesions; the pain did not worsen or lessen with exposure to heat or cold. The physical examination showed periungual erythema with multiple telangiectasias (Fig. 1). A biopsy from periungual skin was taken. Histologic studies revealed increased numbers of dilated blood vessels in the superficial dermis, with rigid walls and normal appearing endothelium (Fig. 2). Specific staining failed to detect acid-alcohol-resistant bacilli., leishmania., or fungi. Capillary microscopy of proximal nailfolds showed diffuse dilated capillaries without avascular areas or hemorrhage. Antinuclear antibody titers were negative, serum levels of creatine and phosphokinase and an electromyogram were normal. The periungual lesions remained unchanged until the patient's death 3 months later due to Pneuniocystis carinii infection.
患有免疫性血小板减少症的同性恋男性的目标血小板抗原。
DOI：
10.1056/nejm198511283132202
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
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作者：
Stricker,RB;Abrams,DI;Corash,L;Shuman,MA
通讯作者：
Shuman,MA