Regulatory Roles of Bone in Neurodegenerative Diseases.
Regulatory Roles of Bone in Neurodegenerative Diseases.
复制标题
骨在神经退行性疾病中的调节作用。
DOI：
10.3389/fnagi.2020.610581
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发表时间：
2020
影响因子：
4.8
通讯作者：
Zou X
中科院分区：
文献类型：
--
作者：
Yu Z;Ling Z;Lu L;Zhao J;Chen X;Xu P;Zou X
骨质疏松症和神经退行性疾病是两种常见的老年人疾病，往往并存。以往的研究表明，骨骼和中枢神经系统与病理生理学密切相关。骨作为人体的主要结构支架，也是干细胞的储存库、初级淋巴器官和重要的内分泌器官。它可以通过各种骨源性细胞与大脑相互作用，主要是间充质干细胞和造血干细胞(HSCs)。骨髓也是产生免疫细胞的地方，这可能会极大地影响大脑功能。最后，骨骼分泌的蛋白质(骨因子)在大脑的生长和功能中也扮演着重要的角色。本文综述了骨源性细胞、骨控制的免疫系统和骨分泌蛋白对脑的影响的最新研究进展，并评价了这些因素在神经退行性疾病的进展中的作用及其在这些疾病的诊断和治疗中的潜在应用。
Osteoporosis and neurodegenerative diseases are two kinds of common disorders of the elderly, which often co-occur. Previous studies have shown the skeletal and central nervous systems are closely related to pathophysiology. As the main structural scaffold of the body, the bone is also a reservoir for stem cells, a primary lymphoid organ, and an important endocrine organ. It can interact with the brain through various bone-derived cells, mostly the mesenchymal and hematopoietic stem cells (HSCs). The bone marrow is also a place for generating immune cells, which could greatly influence brain functions. Finally, the proteins secreted by bones (osteokines) also play important roles in the growth and function of the brain. This article reviews the latest research studying the impact of bone-derived cells, bone-controlled immune system, and bone-secreted proteins on the brain, and evaluates how these factors are implicated in the progress of neurodegenerative diseases and their potential use in the diagnosis and treatment of these diseases.
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影响因子：
11.2
作者：
Chakraborty, Subhankar;Kaur, Sukhwinder;Guha, Sushovan;Batra, Surinder K.
通讯作者：
Batra, Surinder K.
影响因子：
8.2
作者：
Bang OY;Kim EH;Cha JM;Moon GJ
通讯作者：
Moon GJ
影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
DOI：
10.1093/brain/awr074
发表时间：
2011-05
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Beers DR;Henkel JS;Zhao W;Wang J;Huang A;Wen S;Liao B;Appel SH
通讯作者：
Appel SH
影响因子：
15.9
作者：
Brochard, Vanessa;Combadiere, Behazine;Hunot, Stephane
通讯作者：
Hunot, Stephane