Dectin-1 is required for beta-glucan recognition and control of fungal infection.
Dectin-1 is required for beta-glucan recognition and control of fungal infection.
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作者：
β-葡聚糖是真菌病原菌中含量最丰富的多糖之一，但其在抗真菌免疫中的作用尚不清楚。在这里，我们发现β-葡聚糖的髓样受体Dectin-1的缺失使小鼠容易感染白色念珠菌。即使在调理素存在的情况下，缺乏Dectin-1的白细胞对真菌的反应也明显受损。受损的白细胞反应在体内表现为真菌感染后炎性细胞募集减少，导致显著增加的真菌负担和增强的真菌传播。我们的结果建立了Dectin-1识别β-葡聚糖在抗真菌免疫中的基本功能，并证明了诱导保护性免疫反应所需的信号非Toll样模式识别受体。
β-Glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance in antifungal immunity is unclear. Here we show that deficiency of dectin-1, the myeloid receptor for β-glucan, rendered mice susceptible to infection with Candida albicans. Dectin-1-deficient leukocytes demonstrated significantly impaired responses to fungi even in the presence of opsonins. Impaired leukocyte responses were manifested in vivo by reduced inflammatory cell recruitment after fungal infection, resulting in substantially increased fungal burdens and enhanced fungal dissemination. Our results establish a fundamental function for β-glucan recognition by dectin-1 in antifungal immunity and demonstrate a signaling non–Toll-like pattern-recognition receptor required for the induction of protective immune responses.
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影响因子：
64.8
作者：
Hoebe, K;Georgel, P;Beutler, B
通讯作者：
Beutler, B
Dectin-1介导β-葡聚糖的生物学作用。
DOI：
10.1084/jem.20021890
发表时间：
2003-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brown GD;Herre J;Williams DL;Willment JA;Marshall AS;Gordon S
通讯作者：
Gordon S
影响因子：
3.1
作者：
Brieland, J;Essig, D;Hare, R
通讯作者：
Hare, R
影响因子：
56.9
作者：
DICARLO, FJ;FIORE, JV
通讯作者：
FIORE, JV
影响因子：
64.5
作者：
Lo, HJ;Kohler, JR;Fink, GR
通讯作者：
Fink, GR