Dual specificity phosphatase 4 gene expression in association with triple-negative breast cancer outcome.
Dual specificity phosphatase 4 gene expression in association with triple-negative breast cancer outcome.
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DOI：
10.1007/s10549-014-3127-z
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发表时间：
2014-11
影响因子：
3.8
通讯作者：
Shu, Xiao-Ou
中科院分区：
文献类型：
--
作者：
Baglia, Michelle L.;Cai, Qiuyin;Zheng, Ying;Wu, Jie;Su, Yinghao;Ye, Fei;Bao, Ping-Ping;Cai, Hui;Zhao, Zhiguo;Balko, Justin;Zheng, Wei;Lu, Wei;Shu, Xiao-Ou
三阴性乳腺癌(TNBC)是一种侵袭性癌症，治疗选择有限。双特异性磷酸酶4(DUSP4)最近被认为是TNBC化疗耐药的潜在标记物。对参加上海乳腺癌生存研究的469例20~75岁的TNBC患者的乳腺癌组织中DUSP4基因的表达水平进行了检测，并探讨了DUSP4基因表达水平与乳腺癌复发死亡率和总死亡率的关系。通过病历回顾和多次面对面的跟踪调查收集有关乳腺癌诊断、治疗和疾病进展的信息。数据分析采用COX回归模型。在中位数5.3年(范围为0.7-8.9年)的随访中，记录了100例死亡和92例复发/乳腺癌死亡。DUSP4基因转录变异体1(NM_001394)和转录变异体2(NM_057158)的表达水平高度相关(r=0.76)。DUSP4的低表达水平，特别是变异体1，与复发/乳腺癌死亡率的增加和总体死亡率的增加有关。经诊断年龄和TNM分期调整后，低于和高于中位数表达水平的复发/乳腺癌死亡率风险比分别为1.97(95%可信区间：1.27-3.05)和2.09(95%可信区间：1.38-3.17)。对MKI67和TP53、常见治疗类型、乳腺癌亚型和分级的表达水平的额外调整并没有实质性地改变观察到的相关性。低DUSP4表达水平独立于已知的临床和分子预测因素预测TNBC患者的复发和死亡率。
Triple-negative breast cancer (TNBC) is an aggressive cancer with limited treatment options. Dual specificity phosphatase 4 (DUSP4) has recently been suggested as a potential marker of chemotherapy resistance for TNBC. DUSP4 gene expression levels were measured in breast cancer tissue from 469 TNBC patients aged 20 to 75 years who participated in the Shanghai Breast Cancer Survival Study and their association with recurrence/breast cancer mortality and total mortality was evaluated. Information on breast cancer diagnosis, treatment, and disease progression was collected via medical chart review and multiple in-person follow-up surveys. A Cox regression model was applied in the data analyses. Over a median follow-up of 5.3 years (range: 0.7-8.9 years), 100 deaths and 92 recurrences/breast cancer deaths were documented. Expression levels of transcript variant 1 (NM_001394) and transcript variant 2 (NM_057158) of the DUSP4 gene were studied and were highly correlated (r=0.76). Low DUSP4 expression levels, particularly of variant 1, were associated with both increased recurrence/breast cancer mortality and increased overall mortality. Hazard ratios with adjustment for age at diagnosis and TNM stage associated with below versus above the median expression level were 1.97 (95% confidence interval (CI): 1.27-3.05) for recurrence/breast cancer mortality and 2.09 (95% CI: 1.38-3.17) for overall mortality. Additional adjustment for expression levels of MKI67 and TP53, common treatment types, breast cancer subtype, and grade did not materially alter the observed associations. Low DUSP4 expression levels predict recurrence and mortality in TNBC patients independently from known clinical and molecular predictors.
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影响因子：
120.7
作者：
Shu, Xiao Ou;Zheng, Ying;Cai, Hui;Gu, Kai;Chen, Zhi;Zheng, Wei;Lu, Wei
通讯作者：
Lu, Wei
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1186/bcr3327
发表时间：
2012-11-05
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Rottenberg S;Jonkers J
通讯作者：
Jonkers J
影响因子：
50.5
作者：
Guarneri, V.;Piacentini, F.;Conte, P.
通讯作者：
Conte, P.
影响因子：
4.8
作者：
Lawan, Ahmed;Al-Harthi, Sameer;Plevin, Robin
通讯作者：
Plevin, Robin