Prenatal manganese exposure and intrinsic functional connectivity of emotional brain areas in children.
Prenatal manganese exposure and intrinsic functional connectivity of emotional brain areas in children.
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DOI：
10.1016/j.neuro.2017.06.006
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发表时间：
2018-01
期刊：
影响因子：
3.4
通讯作者：
Horton MK
中科院分区：
文献类型：
--
作者：
de Water E;Proal E;Wang V;Medina SM;Schnaas L;Téllez-Rojo MM;Wright RO;Tang CY;Horton MK
锰（Mn）是一种重要的微量金属，在高水平接触时具有神经毒性。在产前期间大脑成熟过程的中断可能会产生持久的后果。在这一关键时期，发育中的人类大脑特别容易受到环境毒物（如锰）的影响，产前锰暴露与参与情绪处理和调节的大脑区域的变化有关。本试点研究的目的是检查产前锰暴露是否与儿童期大脑内在功能连接（iFC）的变化有关，重点是情感脑区的变化。我们从一项正在进行的纵向出生队列研究中选择了15名受试者（年龄6-7岁）参加静息状态功能磁共振成像（fMRI）研究。产前锰暴露量测定从母亲的血液收集在第二和第三孕期。我们使用基于种子的相关性分析和独立成分分析来研究产前锰暴露是否与儿童大脑的iFC相关。我们发现，在控制了社会人口学混杂因素（SES，母亲教育，儿童性别，家庭环境支持）和环境混杂因素（产前铅暴露和空气污染）后，暴露于较高产前锰水平的儿童的右侧苍白球与背侧前扣带皮层和外侧前额叶皮层的iFC降低。这些发现表明，产前锰暴露与儿童参与情绪处理和调节的脑区的iFC减少有关。未来的研究应该调查这种减少的iFC是否介导产前锰暴露和儿童期情绪障碍之间的关联。
Manganese (Mn) is an essential trace metal that is neurotoxic at high levels of exposure. Disruption of brain maturation processes during the prenatal period may have lasting consequences. During this critical period, the developing human brain is uniquely vulnerable to exposure to environmental toxicants such as Mn, and prenatal Mn exposure has been associated with changes in brain areas involved in emotion processing and regulation. The goal of the present pilot study was to examine whether prenatal Mn exposure is associated with changes in the intrinsic functional connectivity (iFC) of the brain in childhood, focusing on changes in emotional brain areas. We selected 15 subjects (age 6–7 years) from an ongoing longitudinal birth cohort study to participate in a resting state functional magnetic resonance imaging (fMRI) study. Prenatal Mn exposure was determined from maternal blood collected during the 2nd and 3rd trimesters of pregnancy. We used seed-based correlation analyses and independent component analyses to examine whether prenatal Mn exposure was associated with the iFC of the brain in children. We found that the right globus pallidus showed reduced iFC with the dorsal anterior cingulate cortex and lateral prefrontal cortex in children who were exposed to higher prenatal Mn levels, after controlling for sociodemographic confounders (SES, maternal education, child sex, home environment support) and environmental confounders (prenatal lead exposure and air pollution). These findings suggest that prenatal Mn exposure is associated with reduced iFC of brain areas involved in emotion processing and regulation in children. Future studies should investigate whether this reduced iFC mediates the association between prenatal Mn exposure and emotional dysfunction in childhood.
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影响因子：
3.4
作者：
Bowler, Rosemarie M.;Koller, William;Schulz, Paul E.
通讯作者：
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作者：
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通讯作者：
Aschner, M
DOI：
10.1073/pnas.0601417103
发表时间：
2006-09-12
影响因子：
11.1
作者：
Damoiseaux, J. S.;Rombouts, S. A. R. B.;Beckmann, C. F.
通讯作者：
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