Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines.

Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines.
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DOI:
10.1016/j.humimm.2009.02.004
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发表时间:
2009-05
期刊:
影响因子:
2.7
通讯作者:
Banchereau, Jacques
Banchereau, Jacques
中科院分区:
医学4区
文献类型:
--
作者:
Klechevsky, Eynav;Liu, Maochang;Morita, Rimpei;Banchereau, Romain;Thompson-Snipes, Luann;Palucka, A. Karolina;Ueno, Hideki;Banchereau, Jacques

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树突状细胞(DC)协调免疫反应,赋予抵抗感染和耐受自我。了解DCs调控免疫和耐受的原理为研究和改善人类疾病治疗的临床结果提供了丰富的基础。几个特征导致DC系统的复杂性。其中,可塑性和存在的子集是突出的决定因素的质量引起的免疫反应。事实上,不同的DC亚群分布在外周组织和血液中,并显示不同的微生物受体、表面分子和细胞因子表达,所有这些都影响免疫结果。分离DC亚群的生物学存在理由一直是许多研究的焦点,包括我们自己的研究,并且正在以人类皮肤DC为重点进行综述。
Dendritic cells (DCs) orchestrate a repertoire of immune responses that endows resistance to infection and tolerance to self. Understanding the principles by which DCs control immunity and tolerance has provided a rich basis for studying and improving clinical outcome of human disease treatment. Several features contribute to the complexity of the DC system. Among these, plasticity and existence of subsets are prominent determinants to the quality of the elicited immune responses. Indeed, different DC subsets are distributed in peripheral tissues and the blood and display different microbial receptors, surface molecules and cytokine expression, all of which influence the immunological outcome. The biological raison d’être for separate DC subsets has been the focus of many studies including our own and is being reviewed with an emphasis on human skin DCs.
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发表时间: 2007-12-24
期刊: The Journal of experimental medicine
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作者:
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