Effects of liver cirrhosis on portal vein embolization prior to right hepatectomy in patients with primary liver cancer.
Effects of liver cirrhosis on portal vein embolization prior to right hepatectomy in patients with primary liver cancer.
复制标题
肝硬化对原发性肝癌患者右肝切除术前门静脉栓塞的影响
DOI：
10.3892/ol.2017.7530
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发表时间：
2018-03
期刊：
影响因子：
2.9
通讯作者：
Zheng SS
中科院分区：
文献类型：
--
作者：
Sun JH;Zhang YL;Nie CH;Li J;Zhou TY;Zhou GH;Zhu TY;Chen LM;Wang WL;Zheng SS
术前门静脉栓塞（PVE）可诱导未来肝残（FLR）的代偿性增生，从而增加原发性肝癌（PLC）患者的可切除性。然而，目前还不清楚它是否在肝硬化患者中相似。因此，本研究调查了PLC患者肝切除前的PVE值，以及PVE后肝硬化对FLR代偿性肥大的影响。在本研究中，21例成功接受PVE后肝切除术的PLC患者进行了回顾性检查。根据有无肝硬化将患者分为非肝硬化组和肝硬化组。比较两组患者的FLR体积。PVE术前、术后4-6周FLR体积差异有统计学意义（P<0.001）。PVE诱导非肝硬化组（P=0.002）和肝硬化组（P<0.001）FLR代偿性肥大。然而，在PVE后4-6周的FLR体积增大方面，两组之间没有显著差异（P=0.373）。总之，PVE肝切除术前可能会促进FLR代偿性肥大和PLC肿瘤的可切除性增加。肝硬化对PVE后肝叶增生无显著影响。
Preoperative portal vein embolization (PVE) induces compensatory hyperplasia of the future liver remnants (FLR), thus increasing resectability in the non-cirrhotic patients with primary liver cancer (PLC). However, it is unclear if it is similar in patients with liver cirrhosis. Therefore, the present study investigated the PVE value prior to liver resection in patients with PLC, and the liver cirrhotic effects on the compensatory hypertrophy of FLRs following PVE. In the present study, 21 patients with PLC who successfully underwent hepatic resection subsequent to PVE, were retrospectively examined. The patients were divided into a non-cirrhosis group and a cirrhosis group according to the absence or presence of cirrhosis, respectively. The FLR volume between the two groups of patients was compared. There was a significant difference in the FLR volume for all patients prior to, and 4–6 weeks following, PVE (P<0.001). PVE induced significant compensatory hypertrophy in the FLRs whether in the non-cirrhosis group (P=0.002) or cirrhosis group (P<0.001). However, no significant difference was identified between the two groups with respect to FLR volume enlargement 4–6 weeks following PVE (P=0.373). In conclusion, PVE prior to hepatectomy may promote FLR compensatory hypertrophy and an increase in the resectability of PLC tumors. No significant effects of liver cirrhosis were identified on liver lobe hyperplasia following PVE.
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影响因子：
9
作者：
Covey, Anne M.;Brown, Karen T.;Fong, Yuman
通讯作者：
Fong, Yuman
DOI：
10.1046/j.1463-1318.2003.00410.x
发表时间：
2003-01-01
期刊：
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
影响因子：
--
作者：
Fusai, G;Davidson, B R
通讯作者：
Davidson, B R
影响因子：
9
作者：
Balzan, S;Belghiti, J;Durand, F
通讯作者：
Durand, F
影响因子：
13.5
作者：
KNODELL, RG;ISHAK, KG;WOLLMAN, J
通讯作者：
WOLLMAN, J
影响因子：
9.6
作者：
Ogata, S.;Belghiti, J.;Vilgrain, V.
通讯作者：
Vilgrain, V.