Modulation of host cell responses and evasion strategies for porcine reproductive and respiratory syndrome virus.
Modulation of host cell responses and evasion strategies for porcine reproductive and respiratory syndrome virus.
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DOI：
10.1016/j.virusres.2010.07.019
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发表时间：
2010-12
期刊：
影响因子：
5
通讯作者：
Liu HC
中科院分区：
文献类型：
--
作者：
Yoo D;Song C;Sun Y;Du Y;Kim O;Liu HC
免疫监视系统保护宿主细胞免受病毒感染，并且病毒已经进化为逃避该系统以在宿主中有效增殖。宿主细胞响应病毒感染产生细胞因子和趋化因子，并且在这些效应分子中，I型干扰素是主要的抗病毒细胞因子，因此是病毒解除宿主监视的有效靶标。猪繁殖与呼吸综合征病毒（Porcine reproductive and respiratory syndrome virus，PRRSV）表达的蛋白质能够绕过干扰素（IFN）反应和其他细胞过程，并且这些蛋白质是多功能的，以补偿PRRSV的小编码能力。迄今为止，至少有四种病毒蛋白已被鉴定和研究作为宿主防御的病毒拮抗剂：作为结构蛋白的N和三种非结构蛋白，Nsp 1（Nsp 1 α和Nsp 1 β），Nsp 2和Nsp 11。其中，N和Nsp 1是分布于细胞核和细胞质中的核质蛋白。Nsp 1和Nsp 2是病毒蛋白酶，而Nsp 11是核糖核酸内切酶。本文综述了目前对这些蛋白在调节宿主先天免疫反应中的作用的认识。阻断病毒介导的先天反应抑制可能会导致未来有效疫苗的开发。了解病毒调节正常细胞过程的机制将是设计PRRS有效控制策略的关键。
The immune surveillance system protects host cells from viral infection, and viruses have evolved to escape this system for efficient proliferation in the host. Host cells produce cytokines and chemokines in response to viral infection, and among such effector molecules, type I interferons are the principal antiviral cytokines and therefore effective targets for viruses to disarm host surveillance. Porcine reproductive and respiratory syndrome virus (PRRSV) expresses proteins that circumvent the IFN response and other cellular processes, and to compensate the small coding capacity of PRRSV, these proteins are multifunctional. To date, at least four viral proteins have been identified and studied as viral antagonists of host defenses: N as a structural protein and three non-structural proteins, Nsp1 (Nsp1α and Nsp1β), Nsp2, and Nsp11. Among these, N and Nsp1 are nuclear-cytoplasmic proteins distributed in both the nucleus and cytoplasm of cells. Nsp1 and Nsp2 are viral proteases while Nsp11 is an endoribonuclease. This review describes the current understanding of the role of these proteins in modulating the host innate immune responses. Blocking against virus-mediated inhibition of the innate response may lead to the future development of effective vaccines. The understanding of viral mechanisms modulating the normal cellular processes will be a key to the design of an effective control strategy for PRRS.
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影响因子：
3
作者：
Barrett, Lisa;Gallant, Maureen;Howley, Constance;Bowmer, M. Ian;Hirsch, Geri;Peltekian, Kevork;Grant, Michael
通讯作者：
Grant, Michael
影响因子：
2.2
作者：
ALBINA, E;MADEC, F;TORRISON, J
通讯作者：
TORRISON, J
影响因子：
5.4
作者：
Baigent, SJ;Zhang, G;McCauley, JW
通讯作者：
McCauley, JW
影响因子：
1.5
作者：
BENFIELD, DA;NELSON, E;CHLADEK, D
通讯作者：
CHLADEK, D
影响因子：
6.4
作者：
De Clercq, Erik
通讯作者：
De Clercq, Erik