The epileptic hypothesis: developmentally related arguments based on animal models.
The epileptic hypothesis: developmentally related arguments based on animal models.
复制标题
DOI：
10.1111/j.1528-1167.2009.02217.x
复制
发表时间：
2009-08
期刊：
影响因子：
5.6
通讯作者：
Moshé SL
中科院分区：
文献类型：
--
作者：
Galanopoulou AS;Moshé SL
与儿童癫痫性脑病相关的显著发病率促使需要识别和剖析导致功能退化的因素和机制。虽然专门评估啮齿动物语言的实验很难设计，但一些研究已经揭示了导致功能退化的条件。特别是，发作间期尖峰和癫痫发作，特别是如果延长或频繁，可能会对大脑功能和发育造成急性或长期影响，这可能会损害各种行为测试的表现。这些影响还受到许多遗传、生物和表观遗传因素的影响，包括年龄、性别和潜在病理学，从而进一步使结局多样化。特别重要的是癫痫疾病表现时的发育年龄，因为它可能决定结果，但也可能是选择适当治疗的决定因素。
The significant morbidity linked to epileptic encephalopathies of childhood has prompted the need to identify and dissect the factors and mechanisms that contribute to the resultant functional regression. Although experiments specifically assessing language in rodents are difficult to design, a number of studies have shed light on the conditions that contribute to the functional deterioration. In particular, interictal spikes and seizures, especially if prolonged or frequent, may cause acute or long-lasting effects on brain functioning and development, which may impair performance in a variety of behavioral tests. These effects are further modified by a number of genetic, biological and epigenetic factors, including age, sex, and underlying pathology, that further diversify outcome. Of special importance is the developmental age when the epileptic disorder manifests, because it may dictate outcome but also may be a deciding factor in selecting appropriate therapies.
登录
查看更多内容
影响因子：
5.3
作者：
Borges, K;Gearing, M;Dingledine, R
通讯作者：
Dingledine, R
影响因子：
11.2
作者：
Cornejo, Brandon J.;Mesches, Michael H.;Benke, Timothy A.
通讯作者：
Benke, Timothy A.
影响因子：
--
作者：
dos Santos, NF;Arida, RM;Cavalheiro, EA
通讯作者：
Cavalheiro, EA
影响因子：
2.5
作者：
DOBBING, J;SANDS, J
通讯作者：
SANDS, J
影响因子：
5.6
作者：
da Silva, AV;Regondi, TC;Spreafico, R
通讯作者：
Spreafico, R