Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges.
Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges.
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长链非编码 RNA 在胆管癌中的新兴作用：进展与挑战。
DOI：
10.1002/cac2.12109
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Jiang Q
中科院分区：
文献类型：
--
作者：
Yang Y;Deng X;Li Q;Wang F;Miao L;Jiang Q
胆管癌（Cholangiocarcinoma，CCA）是一种发病率相对较低的恶性肿瘤，预后较差.目前CCA患者的诊断和治疗方式仍远不令人满意。近年来，许多长链非编码RNA（lncRNA）已被确定为各种癌症（包括CCA）发展的关键参与者。CCA中异常表达的lncRNA受某些上游分子的调控，显著影响肿瘤细胞的生物学行为，并通过多种机制参与肿瘤的发生，包括与功能蛋白的相互作用、参与竞争内源性RNA（ceRNA）调控网络、激活癌症相关信号通路以及基因表达的表观遗传修饰。此外，一些lncRNA与CCA患者的临床病理特征密切相关，是诊断和预测CCA的有希望的生物标志物。这些lncRNA中的一些在化疗药物抗性中起重要作用。此外，lncRNA还被证明参与CCA的炎症微环境和CCA危险因素的恶性结果，如胆汁淤积性肝病。鉴于CCA诊断的困难性，应重视血清或胆汁中可检测的lncRNA。本文综述了近年来关于CCA中lncRNA的研究进展，并从lncRNA的角度对CCA发生发展的分子机制进行了展望。此外，我们还讨论了目前研究的局限性和lncRNA在不同类型CCA中的差异表达。
Cholangiocarcinoma (CCA), a cancer with a relatively low incidence rate, is usually associated with poor prognosis. Current modalities for the diagnosis and treatment of CCA patients are still far from satisfactory. In recent years, numerous long noncoding RNAs (lncRNAs) have been identified as crucial players in the development of various cancers, including CCA. Abnormally expressed lncRNAs in CCA, regulated by some upstream molecules, significantly influence the biological behavior of tumor cells and are involved in tumor development through various mechanisms, including interactions with functional proteins, participation in competing for endogenous RNA (ceRNA) regulatory networks, activation of cancer‐related signaling pathways and epigenetic modification of gene expression. Furthermore, several lncRNAs are closely associated with the clinicopathological features of CCA patients, and are promising biomarkers for diagnosing and prognostication of CCA. Some of these lncRNAs play an important role in chemotherapy drug resistance. In addition, lncRNAs have also been shown to be involved in the inflammation microenvironment of CCA and malignant outcome of CCA risk factors, such as cholestatic liver diseases. In view of the difficulty of diagnosing CCA, more attention should be paid to detectable lncRNAs in the serum or bile. This review summarizes the recent knowledge on lncRNAs in CCA and provides a new outlook on the molecular mechanisms of CCA development from the perspective of lncRNAs. Moreover, we also discussed the limitations of the current studies and differential expression of lncRNAs in different types of CCA.
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影响因子：
11.1
作者：
Cheng D;Deng J;Zhang B;He X;Meng Z;Li G;Ye H;Zheng S;Wei L;Deng X;Chen R;Zhou J
通讯作者：
Zhou J
影响因子：
1.6
作者：
Andrici J;Goeppert B;Sioson L;Clarkson A;Renner M;Stenzinger A;Tayao M;Watson N;Farzin M;Toon CW;Smith RC;Mittal A;Samra JS;Hugh TJ;Chou A;Lawlor RT;Weichert W;Schirmacher P;Sperandio N;Ruzzenente A;Scarpa A;Gill AJ
通讯作者：
Gill AJ
DOI：
10.1146/annurev-pathol-052016-100322
发表时间：
2017-01-24
期刊：
Annual review of pathology
影响因子：
--
作者：
Affo S;Yu LX;Schwabe RF
通讯作者：
Schwabe RF
影响因子：
3.4
作者：
Bai, Jian-Guo;Tang, Rui-Feng;Sun, Chao
通讯作者：
Sun, Chao
影响因子：
2.9
作者：
Bao, Wenqing;Cao, Feng;Zhao, Bin
通讯作者：
Zhao, Bin