Cellular interactions involved in the determination of the early C. elegans embryo
Cellular interactions involved in the determination of the early C. elegans embryo
复制标题
细胞相互作用参与早期秀丽隐杆线虫胚胎的测定
DOI：
10.1016/0925-4773(91)90046-9
复制
发表时间：
1991
影响因子：
2.6
通讯作者：
R. Schnabel
中科院分区：
文献类型：
--
作者：
R. Schnabel
经典的工作暗示早期线虫胚胎发生是完全镶嵌的。这一观点最近受到了inC. elegansan早期相互作用必须发生以诱导从卵裂球产生肌肉。在这里，早期胚胎卵裂球被激光显微手术灭活。将辐照胚胎的细胞谱系与完整胚胎的细胞谱系进行比较。结果表明，一个卵裂球，MS，是需要规范的中胚层咽的命运和另一个卵裂球，P2，从AB卵裂球的后代的真皮下的命运的规范，而神经系统的适当规范需要两者的存在。第三个卵裂球的照射表明，相互作用也发生在外胚层内。我建议C.可以通过两个主要信号随后是次级相互作用来建立优美胚。所提出的机制让人想起那些参与两栖动物的发展。
Classical work implied that early nematode embryogenesis is completely mosaic. This view was lately challenged by the demonstration that inC. elegansan early interaction has to occur to induce the production of muscle from a blastomere. Here, early embryonic blastomeres were inactivated by laser microsurgery. The cell lineages of irradiated embryos were compared to those of intact embryos. It is shown that one blastomere, MS, is required for the specification of mesodermal pharyngeal fates and another blastomere, P2, for the specification of hypodermal fates from the descendants of the AB blastomere, whereas the proper specification of the nervous system requires the presence of both. The irradiation of a third blastomere shows that interactions also occur within the ectoderm. I propose that the body plan of theC. elegansembryo may be established by two primary signals followed by secondary interactions. The suggested mechanisms are reminiscent of those involved in amphibian development.
影响因子：
2.7
作者：
PRIESS, JR;HIRSH, DI
通讯作者：
HIRSH, DI
胚胎如何工作：细胞命运规范不同模式的比较观点。
DOI：
10.1242/dev.108.3.365
发表时间：
1990
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Davidson,EH
通讯作者：
Davidson,EH