SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization.
SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization.
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DOI：
10.1016/j.celrep.2021.109017
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发表时间：
2021-04-20
期刊：
影响因子：
8.8
通讯作者：
Pöhlmann S
中科院分区：
文献类型：
--
作者：
Hoffmann M;Zhang L;Krüger N;Graichen L;Kleine-Weber H;Hofmann-Winkler H;Kempf A;Nessler S;Riggert J;Winkler MS;Schulz S;Jäck HM;Pöhlmann S
在欧洲和美国，已经观察到严重急性呼吸综合征冠状病毒2(SARS-CoV-2)从人到养殖水貂的传播。在受感染的动物中，出现了包含中和抗体靶标的尖峰蛋白(S)突变的病毒变异，这些变异被传播回人类。这引起了人们的担忧，即水貂可能成为人类感染SARS-CoV-2变种的持续来源，与对人类健康的威胁增加相关，并导致水貂被大规模扑杀。在这里，我们报告了水貂SARS-CoV-2的S蛋白的频繁突变与其有效进入人类细胞及其被可溶性血管紧张素转换酶2(ACE2)的抑制作用相一致。相比之下，突变Y453F减少了获得2019年冠状病毒病(新冠肺炎)治疗和新冠肺炎患者血清/血浆紧急使用授权的抗体的中和作用。这些结果表明，感染后诱导的抗体反应或用于治疗的某些抗体可能对水貂的SARS-CoV-2变异株没有足够的保护作用。SARS-CoV-2在人和养殖水貂之间的传播引起了人们的担忧，因为水貂携带的病毒已经获得了刺突蛋白的突变。霍夫曼等人。结果表明，这些水貂特有的突变不会增加进入人类细胞的数量，但确实会导致部分逃避治疗性抗体和恢复期血浆/血清的中和。
Transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans to farmed mink has been observed in Europe and the US. In the infected animals, viral variants arose that harbored mutations in the spike (S) protein, the target of neutralizing antibodies, and these variants were transmitted back to humans. This raised concerns that mink might become a constant source of human infection with SARS-CoV-2 variants associated with an increased threat to human health and resulted in mass culling of mink. Here, we report that mutations frequently found in the S proteins of SARS-CoV-2 from mink are mostly compatible with efficient entry into human cells and its inhibition by soluble angiotensin-converting enzyme 2 (ACE2). In contrast, mutation Y453F reduces neutralization by an antibody with emergency use authorization for coronavirus disease 2019 (COVID-19) therapy and sera/plasma from COVID-19 patients. These results suggest that antibody responses induced upon infection or certain antibodies used for treatment might offer insufficient protection against SARS-CoV-2 variants from mink. Transmission of SARS-CoV-2 between humans and farmed mink has caused concern because viruses from mink have acquired mutations in the spike protein. Hoffmann et al. show that these mink-specific mutations do not increase entry into human cells but do cause partial evasion from neutralization by a therapeutic antibody and convalescent plasma/sera.
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