Partners with a killer: Metabolic signaling promotes inflammatory cell death.
Partners with a killer: Metabolic signaling promotes inflammatory cell death.
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DOI:
10.1016/j.cell.2021.07.036
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发表时间:
2021-08-19
期刊:
影响因子:
64.5
通讯作者:
Xiao, Tsan Sam
中科院分区:
文献类型:
--
作者:
Liu, Zhonghua;Xiao, Tsan Sam
In this issue of Cell, report that mTOR Complex 1 (mTORC1), a metabolic signaling complex, controls reactive oxygen species (ROS) production in mitochondria, which in turn promotes inflammatory cell death mediated by gasdermin D (GSDMD). This provides a new mechanistic connection between metabolic signaling and inflammatory cell death.
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