Effects of age, hypertension and HRT on serum aminopeptidase A activity.
Effects of age, hypertension and HRT on serum aminopeptidase A activity.
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年龄、高血压和 HRT 对血清氨肽酶 A 活性的影响。
DOI：
10.1016/s0378-5122(02)00207-4
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发表时间：
2002
期刊：
影响因子：
4.9
通讯作者：
S. Mizutani
中科院分区：
文献类型：
--
作者：
M. Ijima;S. Nomura;M. Okada;Y. Ikoma;Tomomi Ito;Takashi Mitsui;O. Maeda;S. Mizutani
目的认为氨肽酶A /血管紧张酶参与了高血压的发病过程。本研究的目的是评估年龄、高血压和激素替代治疗（HRT）对中老年妇女血清APA活性的影响。方法选取年龄在40 ~ 69岁之间的女性117例，未接受HRT治疗的正常健康女性48例，接受HRT治疗的正常健康女性57例，未接受药物治疗的高血压女性12例（血压为140/90 mmHg）。以α-谷氨酰对硝基苯胺为底物分光光度法测定血清APA活性。结果未接受HRT的健康女性血清APA活性随年龄增加而升高（r=0.351， P<0.05）。高血压妇女的血清APA活性高于同龄正常妇女（25.4±4.2 vs 22.4±3.4 μM/min， P<0.05）。与未接受HRT的妇女相比，接受HRT的妇女的血清APA活性升高（23.9±3.8 vs 20.4±3.2 μM/min， P<0.05）。结论健康女性血清中sapa活性与年龄呈正相关。此外，高血压和HRT显著上调血清APA活性。血清APA的测量对于阐明APA的生理和临床作用有价值，尽管还需要进一步的研究。
ObjectivesIt is conceivable that aminopeptidase A (APA)/angiotensinase is involved in the pathogenesis of hypertension. The aim of this study was to evaluate the influences of age, hypertension and hormone replacement therapy (HRT) on serum APA activity in middle-aged and elderly women.MethodsBlood samples were collected from 117 women aged 40–69, 48 normotensive healthy women not receiving HRT, 57 normotensive women receiving HRT, and 12 hypertensive women (blood pressure >140/90 mmHg) with no medication. Serum APA activity was measured using α-glutamyl-p-nitroanilide as substrate spectrophotometrically.ResultsSerum APA activity increased along with age between 40 and 69 in healthy women not taking HRT (r=0.351, P<0.05). Hypertensive women had higher serum APA activity than age-matched normotensive women (25.4±4.2 versus 22.4±3.4 μM/min; P<0.05) Compared with non-users of HRT, APA activity was elevated in women receiving HRT (23.9±3.8 versus 20.4±3.2 μM/min; P<0.05).ConclusionsAPA activity had a positive correlation with age in healthy women. Furthermore, hypertension and HRT up-regulated the serum APA activity significantly. The measurements of serum APA would be of value to elucidate the physiological and clinical roles of APA, although further studies are required.
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
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通讯作者：
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