FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition.
FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition.
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DOI：
10.3389/fonc.2020.01685
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发表时间：
2020
影响因子：
4.7
通讯作者：
Jiang H
中科院分区：
文献类型：
--
作者：
Yang C;Zhang Z;Ye F;Mou Z;Chen X;Ou Y;Xu C;Wu S;Cheng Z;Hu J;Zou L;Jiang H
成纤维细胞生长因子18（FGF 18）是FGF家族的成员，并有助于广泛的生物学事件。已经确定了FGF 18过表达在几种类型的癌症进展中的重要作用。然而，关于FGF 18在肾透明细胞癌（ccRCC）中的生物学作用的信息仍然很少，这对于研究FGF 18在ccRCC中的生物学功能是有意义的。我们的结果显示，与来自华山医院TCGA数据库和临床队列的配对正常肾组织相比，FGF 18在ccRCC组织中低表达，并且FGF 18的高表达与ccRCC患者的良好预后相关。此外，FGF 18的过表达在体外和体内显著抑制ccRCC细胞系的增殖能力。基因集富集分析（GSEA）鉴定了在TCGA组群中的ccRCC患者的高FGF 18表达组中涉及的上皮-间质转化（EMT），这用FGF 18过表达的ccRCC细胞系中的EMT相关标志物进一步验证。此外，FGF 18过表达显著抑制ccRCC细胞中的PI 3 K/Akt通路。总而言之，本研究得出的结论是，FGF 18作为ccRCC的靶点具有潜在价值。
Fibroblast growth factor 18 (FGF18) is a member of the FGF family and contributes to a broad range of biological events. The important role of the overexpression of FGF18 has been identified in the progression of several types of cancers. However, there is still little information on the biological role of FGF18 on clear cell renal cell carcinoma (ccRCC), which is of interest in investigating the biological functions of FGF18 in ccRCC. Our results showed that FGF18 was lowly expressed in ccRCC tissues compared to paired normal renal tissue from the TCGA database and clinical cohort of Huashan Hospital and that high expression of FGF18 correlated with a good prognosis in ccRCC patients. In addition, overexpression of FGF18 significantly inhibited the proliferation ability of ccRCC cell lines in vitro and in vivo. Gene set enrichment analysis (GSEA) identified epithelial-mesenchymal transition (EMT) involved in a high FGF18 expression group of ccRCC patients in the TCGA cohort, which was further validated with EMT related markers in FGF18 overexpressed ccRCC cell lines. Furthermore, FGF18 overexpression significantly inhibited the PI3K/Akt pathway in ccRCC cells. Taken together, this study concludes that FGF18 is of potential value as a target for ccRCC.
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影响因子：
9
作者：
Chang, L.;Graham, P. H.;Hao, J.;Ni, J.;Bucci, J.;Cozzi, P. J.;Kearsley, J. H.;Li, Y.
通讯作者：
Li, Y.
影响因子：
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50.5
作者：
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通讯作者：
Signoretti, S.
影响因子：
8
作者：
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通讯作者：
Gilles, C.