Neutralization escape of Omicron XBB, BR.2, and BA.2.3.20 subvariants.
Neutralization escape of Omicron XBB, BR.2, and BA.2.3.20 subvariants.
复制标题
DOI：
10.1016/j.xcrm.2023.101049
复制
发表时间：
2023-05-16
影响因子：
14.3
通讯作者：
Liu, Shan-Lu
中科院分区：
文献类型：
--
作者：
Faraone, Julia N.;Qu, Panke;Evans, John P.;Zheng, Yi-Min;Carlin, Claire;Anghelina, Mirela;Stevens, Patrick;Fernandez, Soledad;Jones, Daniel;Lozanski, Gerard;Panchal, Ashish;Saif, Linda J.;Oltz, Eugene M.;Gumina, Richard J.;Liu, Shan-Lu
新的奥密克戎亚变体在全球不断出现。特别是XBB亚变体，它是BA.2.10.1.1和BA.2.75.3.1.1.1之间的重组病毒，以及含有不同于BA.2和BA.2.75的突变的BA.2.3.20和BR.2亚变体，目前在测序的变体中所占比例正在增加。在此我们表明，由3剂mRNA加强针疫苗接种以及BA.1和BA.4/5波感染所诱导的抗体能有效中和BA.2、BR.2和BA.2.3.20，但对XBB的中和效率显著降低。此外，BA.2.3.20亚变体在肺源的CaLu - 3细胞和293T - ACE2细胞中表现出增强的传染性。总体而言，我们的结果表明XBB亚变体具有高度的中和抗性，这凸显了持续监测新出现的奥密克戎亚变体的免疫逃逸和组织嗜性的必要性。
3剂mRNA疫苗接种诱导的抗体几乎不能中和XBB
BA.1和BA.4/5感染诱导的抗体对XBB的中和作用较弱
BR.2和BA.2.3.20与亲本BA.2具有相似的中和作用
BA.2.3.20在肺源的CaLu - 3细胞中表现出增强的传染性
法龙等人研究了奥密克戎亚变体BR.2、BA.2.3.20和XBB的传染性和中和作用。他们表明，对于3剂mRNA疫苗接种或自然的BA.1或BA.4/5感染，XBB具有显著的中和逃逸能力，但BR.2和BA.2.3.20则没有。BA.2.3.20在肺源的CaLu - 3细胞中也表现出增强的传染性。
New Omicron subvariants continue to emerge throughout the world. In particular, the XBB subvariant, which is a recombinant virus between BA.2.10.1.1 and BA.2.75.3.1.1.1, as well as the BA.2.3.20 and BR.2 subvariants that contain mutations distinct from BA.2 and BA.2.75, are currently increasing in proportion of variants sequenced. Here we show that antibodies induced by 3-dose mRNA booster vaccination as well as BA.1- and BA.4/5-wave infection effectively neutralize BA.2, BR.2, and BA.2.3.20 but have significantly reduced efficiency against XBB. In addition, the BA.2.3.20 subvariant exhibits enhanced infectivity in the lung-derived CaLu-3 cells and in 293T-ACE2 cells. Overall, our results demonstrate that the XBB subvariant is highly neutralization resistant, which highlights the need for continued monitoring of the immune escape and tissue tropism of emerging Omicron subvariants. 3-dose mRNA vaccination-induced antibodies barely neutralize XBB BA.1 and BA.4/5 infection-induced antibodies weakly neutralize XBB BR.2 and BA.2.3.20 have similar neutralization to the parental BA.2 BA.2.3.20 exhibits enhanced infectivity in the lung-derived CaLu-3 cells Faraone et al. investigate the infectivity and neutralization of Omicron subvariants BR.2, BA.2.3.20, and XBB. They show remarkable neutralization escape by XBB, but not BR.2 and BA.2.3.20, for 3-dose mRNA vaccination or natural BA.1 or BA.4/5 infection. BA.2.3.20 also exhibits enhanced infectivity in the lung-derived CaLu-3 cells.
登录
查看更多内容
影响因子：
30.3
作者：
Qu, Panke;Evans, John P.;Faraone, Julia N.;Zheng, Yi-Min;Carlin, Claire;Anghelina, Mirela;Stevens, Patrick;Fernandez, Soledad;Jones, Daniel;Lozanski, Gerard;Panchal, Ashish;Saif, Linda J.;Oltz, Eugene M.;Xu, Kai;Gumina, Richard J.;Liu, Shan-Lu
通讯作者：
Liu, Shan-Lu
影响因子：
30.3
作者：
Evans, John P.;Zeng, Cong;Qu, Panke;Faraone, Julia;Zheng, Yi-Min;Carlin, Claire;Bednash, Joseph S.;Zhou, Tongqing;Lozanski, Gerard;Mallampalli, Rama;Saif, Linda J.;Oltz, Eugene M.;Mohler, Peter J.;Xu, Kai;Gumina, Richard J.;Liu, Shan-Lu
通讯作者：
Liu, Shan-Lu
影响因子：
56.9
作者：
Yuan, Shuofeng;Ye, Zi-Wei;Chan, Jasper Fuk-Woo
通讯作者：
Chan, Jasper Fuk-Woo
影响因子：
64.8
作者：
Shuai, Huiping;Chan, Jasper Fuk-Woo;Chu, Hin
通讯作者：
Chu, Hin
影响因子：
8.4
作者：
Goerke, Aaron R.;Loening, Andreas M.;Swartz, James R.
通讯作者：
Swartz, James R.