Clinical Predictors of Prolonged Hospital Stay in Patients with Myasthenia Gravis: A Study Using Machine Learning Algorithms.
Clinical Predictors of Prolonged Hospital Stay in Patients with Myasthenia Gravis: A Study Using Machine Learning Algorithms.
复制标题
重症肌无力患者住院时间延长的临床预测因素：一项使用机器学习算法的研究。
DOI：
10.3390/jcm10194393
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发表时间：
2021-09-26
影响因子：
3.9
通讯作者：
Lu CJ
中科院分区：
文献类型：
--
作者：
Chang CC;Yeh JH;Chen YM;Jhou MJ;Lu CJ
重症肌无力（MG）是一种自身免疫性疾病，导致肌肉无力。虽然管理是完善的，但有些患者是难治性的，需要延长住院时间。我们的研究旨在通过使用机器学习方法来确定预测MG患者住院时间的重要因素。总共选择了21个因素进行机器学习分析。我们回顾性分析了MG住院患者的资料。五种机器学习方法，包括随机梯度提升（SGB），最小绝对收缩和选择算子（Lasso），岭回归（Ridge），极端梯度提升（XGboost）和分类特征支持的梯度提升（Catboost），用于构建模型以识别影响住院时间的重要因素。共204例住院MG患者的232个数据点入组研究。MGFA分类、大剂量静脉皮质类固醇治疗、入院时年龄、静脉免疫球蛋白治疗和胸腺瘤是影响住院时间延长的前5个重要变量。我们的机器学习研究结果将为医生提供信息，以评估MG患者延长住院时间的潜在风险。使用大剂量皮质类固醇与住院时间延长相关，MG患者应谨慎使用。
Myasthenia gravis (MG) is an autoimmune disorder that causes muscle weakness. Although the management is well established, some patients are refractory and require prolonged hospitalization. Our study is aimed to identify the important factors that predict the duration of hospitalization in patients with MG by using machine learning methods. A total of 21 factors were chosen for machine learning analyses. We retrospectively reviewed the data of patients with MG who were admitted to hospital. Five machine learning methods, including stochastic gradient boosting (SGB), least absolute shrinkage and selection operator (Lasso), ridge regression (Ridge), eXtreme gradient boosting (XGboost), and gradient boosting with categorical features support (Catboost), were used to construct models for identify the important factors affecting the duration of hospital stay. A total of 232 data points of 204 hospitalized MG patients admitted were enrolled into the study. The MGFA classification, treatment of high-dose intravenous corticosteroid, age at admission, treatment with intravenous immunoglobulins, and thymoma were the top five significant variables affecting prolonged hospitalization. Our findings from machine learning will provide physicians with information to evaluate the potential risk of MG patients having prolonged hospital stay. The use of high-dose corticosteroids is associated with prolonged hospital stay and to be used cautiously in MG patients.
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影响因子：
4.1
作者：
Coutinho, Agnes E.;Chapman, Karen E.
通讯作者：
Chapman, Karen E.
影响因子：
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Kaminski, H. J.
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Friedman, JH
通讯作者：
Friedman, JH