Artemisinin-resistant malaria: research challenges, opportunities, and public health implications.
Artemisinin-resistant malaria: research challenges, opportunities, and public health implications.
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DOI：
10.4269/ajtmh.2012.12-0025
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Dondorp AM
中科院分区：
文献类型：
--
作者：
Fairhurst RM;Nayyar GML;Breman JG;Hallett R;Vennerstrom JL;Duong S;Ringwald P;Wellems TE;Plowe CV;Dondorp AM
以青蒿素为基础的联合疗法是治疗恶性疟原虫疟疾的最有效药物。对青蒿素单一疗法的敏感性降低，加上寄生虫对所有伙伴药物产生抗药性，可能使数百万疟疾患者面临得不到充分治疗的风险。认识到这种可能性的重要性和紧迫性，福格蒂国际中心和美国国立卫生研究院国家过敏和传染病研究所于2010年11月召开了一次会议，召集了应对青蒿素耐药性日益增长的威胁的各种利益攸关方，包括来自处于危险之中的疟疾流行国家的科学家。这次会议鼓励并使专家们能够分享他们最近未发表的研究数据，这些数据可能会提高我们对青蒿素耐药性的认识。会议讨论了预防青蒿素耐药性的研究重点，并促进了实地和实验室研究人员与国际项目之间的合作，目的是将新的科学证据转化为公共卫生解决方案。受这次会议的启发，本综述总结了关于青蒿素耐药性的新发现和观点，将研究数据转化为相关公共卫生信息的方法，以及跨学科合作对抗青蒿素耐药性的机会。
Artemisinin-based combination therapies are the most effective drugs to treat Plasmodium falciparum malaria. Reduced sensitivity to artemisinin monotherapy, coupled with the emergence of parasite resistance to all partner drugs, threaten to place millions of patients at risk of inadequate treatment of malaria. Recognizing the significance and immediacy of this possibility, the Fogarty International Center and the National Institute of Allergy and Infectious Diseases of the U.S. National Institutes of Health convened a conference in November 2010 to bring together the diverse array of stakeholders responding to the growing threat of artemisinin resistance, including scientists from malarious countries in peril. This conference encouraged and enabled experts to share their recent unpublished data from studies that may improve our understanding of artemisinin resistance. Conference sessions addressed research priorities to forestall artemisinin resistance and fostered collaborations between field- and laboratory-based researchers and international programs, with the aim of translating new scientific evidence into public health solutions. Inspired by this conference, this review summarizes novel findings and perspectives on artemisinin resistance, approaches for translating research data into relevant public health information, and opportunities for interdisciplinary collaboration to combat artemisinin resistance.
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影响因子：
3.7
作者：
Carrara, Verena Ilona;Zwang, Julien;Ashley, Elizabeth A.;Price, Ric N.;Stepniewska, Kasia;Barends, Marion;Brockman, Alan;Anderson, Tim;McGready, Rose;Phaiphun, Lucy;Proux, Stephane;van Vugt, Michele;Hutagalung, Robert;Lwin, Khin Maung;Phyo, Aung Pyae;Preechapornkul, Piyanuch;Imwong, Mallika;Pukrittayakamee, Sasithon;Singhasivanon, Pratap;White, Nicholas J.;Nosten, Francois
通讯作者：
Nosten, Francois
影响因子：
4.8
作者：
Bhisutthibhan, J;Pan, XQ;Meshnick, SR
通讯作者：
Meshnick, SR
影响因子：
168.9
作者：
Dondorp, Arjen M.;Fanello, Caterina I.;White, Nicholas J.
通讯作者：
White, Nicholas J.
影响因子：
4.9
作者：
Humphreys, G. S.;Merinopoulos, I.;Hallett, R. L.
通讯作者：
Hallett, R. L.
影响因子：
64.8
作者：
Eckstein-Ludwig, U;Webb, RJ;Krishna, S
通讯作者：
Krishna, S