Constraint-induced intervention as an emergent phenomenon from synaptic competition in biological systems.
Constraint-induced intervention as an emergent phenomenon from synaptic competition in biological systems.
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DOI：
10.1007/s10827-021-00782-9
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发表时间：
2021-05
影响因子：
1.2
通讯作者：
Sanger TD
中科院分区：
文献类型：
--
作者：
Sohn WJ;Sanger TD
强制诱导疗法的原理在康复中被广泛应用。在偏瘫型脑性瘫痪（CP）中，由于单侧损伤导致对侧皮质脊髓投射受损，在对受影响较少的半球的肢体施加临时限制后，功能得到改善。这种类型的部分可逆的损害运动控制的早期脑损伤具有相似的经验依赖性塑料收购和修改的神经元反应的选择性在视觉皮层。在此之前，这种机制被建模的框架内的突触修饰（Bienenstock-Cooper-Munro）理论，基于速率的突触修饰理论。在这里，我们展示了一个最低限度的复杂但足够的神经网络模型，它提供了一个基本的解释半球间的竞争使用一个简化的尖峰为基础的模型的信息传输和可塑性。我们通过模拟同侧和对侧皮质脊髓束细胞之间的竞争来模拟偏瘫CP的功能恢复。我们使用一个高速硬件神经模拟，以提供现实数量的尖峰和突触修改的现实幅度。我们证明，约束诱导的半身不遂部分逆转现象可以通过简化的神经下行束来建模，该神经下行束具有2层发放神经元和具有发放时间依赖性可塑性（STDP）的突触。我们进一步证明，持续性偏瘫后，单侧皮质失活或剥夺是预测的STDP为基础的模型，但不一致的STDP模型。虽然我们的模型是一个高度简化和有限的代表性的皮质脊髓系统，它提供了一个解释如何约束作为一种干预可以帮助系统摆脱一个次优的解决方案。这是突触竞争中涌现现象的一种表现。在线版本包含补充材料，可通过10.1007/s10827-021-00782-9获得。
The principle of constraint-induced therapy is widely practiced in rehabilitation. In hemiplegic cerebral palsy (CP) with impaired contralateral corticospinal projection due to unilateral injury, function improves after imposing a temporary constraint on limbs from the less affected hemisphere. This type of partially-reversible impairment in motor control by early brain injury bears a resemblance to the experience-dependent plastic acquisition and modification of neuronal response selectivity in the visual cortex. Previously, such mechanism was modeled within the framework of BCM (Bienenstock-Cooper-Munro) theory, a rate-based synaptic modification theory. Here, we demonstrate a minimally complex yet sufficient neural network model which provides a fundamental explanation for inter-hemispheric competition using a simplified spike-based model of information transmission and plasticity. We emulate the restoration of function in hemiplegic CP by simulating the competition between cells of the ipsilateral and contralateral corticospinal tracts. We use a high-speed hardware neural simulation to provide realistic numbers of spikes and realistic magnitudes of synaptic modification. We demonstrate that the phenomenon of constraint-induced partial reversal of hemiplegia can be modeled by simplified neural descending tracts with 2 layers of spiking neurons and synapses with spike-timing-dependent plasticity (STDP). We further demonstrate that persistent hemiplegia following unilateral cortical inactivation or deprivation is predicted by the STDP-based model but is inconsistent with BCM model. Although our model is a highly simplified and limited representation of the corticospinal system, it offers an explanation of how constraint as an intervention can help the system to escape from a suboptimal solution. This is a display of an emergent phenomenon from the synaptic competition. The online version contains supplementary material available at 10.1007/s10827-021-00782-9.
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影响因子：
3.4
作者：
Friel KM;Williams PT;Serradj N;Chakrabarty S;Martin JH
通讯作者：
Martin JH
影响因子：
16.2
作者：
Espinosa JS;Stryker MP
通讯作者：
Stryker MP
DOI：
10.1007/s004170050276
发表时间：
1999-07-01
影响因子：
2.7
作者：
Joosse, MV;Simonsz, HJ;de Jong, PTVM
通讯作者：
de Jong, PTVM
影响因子：
8.2
作者：
Eyre, J. A.
通讯作者：
Eyre, J. A.
影响因子：
2.9
作者：
Izhikevich, EM;Desai, NS
通讯作者：
Desai, NS